ArticleMolecular and cellular biochemistry2002
Protective effects of antioxidative serotonin derivatives isolated from safflower against postischemic myocardial dysfunction.
Article in Molecular and cellular biochemistry, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 55 citations in OpenAlex.
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- Assessment of Metabolic Profiles in Florets ofMetabolites · 2020Article
- N-(p-coumaroyl) serotonin inhibits glioblastoma cells growth through triggering S-phase arrest and apoptosis.Journal of neuro-oncology · 2017Article
- Mixed seeds juice with high antioxidant capacity and digestive enzyme activity and its application.Food science and biotechnology · 2017Article
- Regulatory roles of serotonin and melatonin in abiotic stress tolerance in plants.Plant signaling & behavior · 2015Review
- Phytoserotonin: a review.Plant signaling & behavior · 2011Review
- Effects of Flos carthami on CYP2D6 and on the Pharmacokinetics of Metoprolol in Rats.Evidence-based complementary and alternative medicine : eCAM · 2011Article
- Carthamus tinctorius Enhances the Antitumor Activity of Dendritic Cell Vaccines via Polarization toward Th1 Cytokines and Increase of Cytotoxic T Lymphocytes.Evidence-based complementary and alternative medicine : eCAM · 2011Article
- Effects of safflower seed extract on arterial stiffness.Vascular health and risk management · 2010Article
- Retrospect and prospect of active principles from Chinese herbs in the treatment of dementia.Acta pharmacologica Sinica · 2010Review
- Protective effects of sarpogrelate, a 5-HT2A antagonist, against postischemic myocardial dysfunction in guinea-pig hearts.Molecular and cellular biochemistry · 2005Article
- Production of coumaroylserotonin and feruloylserotonin in transgenic rice expressing pepper hydroxycinnamoyl-coenzyme A:serotonin N-(hydroxycinnamoyl)transferase.Plant physiology · 2004Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
N-(p-Coumaroyl)serotonin (C) and N-feruroylserotonin (F) with antioxidative activity are present in safflower oil. The protective effects of C and F were investigated in perfused guinea-pig Langendorff hearts subjected to ischemia and reperfusion. Changes in cellular levels of high phosphorous energy, NO and Ca2+ in the heart together with simultaneous recordings of left ventricular developed pressure (LVDP) were monitored by an nitric oxide (NO) electrode, fluorometry and 31P-NMR. The rate of recovery of LVDP from ischemia by reperfusion was 30.8% in the control, while in the presence of C or F a gradual increase to 63.2 or 61.0% was observed. Changes of transient NO signals (TNO) released from heart tissue in one contraction (LVDP) were observed to be upside-down with respect to transient fura-2-Ca2+ signals (TCa) and transient O2 signals detected with a pO2 electrode. At the final stage of ischemia, the intracellular concentration of Ca2+ ([Ca2+]i) and the release of NO increased with no twitching and remained at a high steady level. The addition of C increased the NO level at the end of ischemia compared with the control, but [Ca2+]i during ischemia decreased. On reperfusion, the increased diastolic level of TCa and TNO returned rapidly to the control level with the recovery of LVDP. By in vitro EPR, C and F were found to directly quench the activity of active radicals. Therefore, it is concluded that the antioxidant effects of two derivatives isolated from safflower play an important role in ischemia-reperfusion hearts in close relation with NO.
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