ArticleBiophysical journal2002
Real-time measurement of spontaneous antigen-antibody dissociation.
Article in Biophysical journal, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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Who cites it
16 citing papers in PubMed.
- Combining DNA scaffolds and acoustic force spectroscopy to characterize individual protein bonds.Biophysical journal · 2023Article
- Calculating the force-dependent unbinding rate of biological macromolecular bonds from force-ramp optical trapping assays.Scientific reports · 2022Article
- Quantification of Antibody Persistence for Cell Surface Protein Labeling.Cellular and molecular bioengineering · 2021Article
- Rapid detection of SARS-CoV-2 antibodies using electrochemical impedance-based detector.Biosensors & bioelectronics · 2021Article
- Functionalized gold nanorod nanocomposite system to modulate differentiation of human mesenchymal stem cells into neural-like progenitors.Scientific reports · 2017Article
- Modifying Dendritic Cell Activation with Plasmonic Nano Vectors.Scientific reports · 2017Article
- Triple-negative breast cancer targeting and killing by EpCAM-directed, plasmonically active nanodrug systems.NPJ precision oncology · 2017Article
- Circulating tumor cell identification by functionalized silver-gold nanorods with multicolor, super-enhanced SERS and photothermal resonances.Scientific reports · 2014Article
- Nanostructures of designed geometry and functionality enable regulation of cellular signaling processes.Biochemistry · 2012Article
- Engineered nanostructures of antigen provide an effective means for regulating mast cell activation.ACS nano · 2011Article
- Surface-bound selectin-ligand binding is regulated by carrier diffusion.European biophysics journal : EBJ · 2009Article
- Optical tweezers to study single protein A/immunoglobulin G interactions at varying conditions.European biophysics journal : EBJ · 2008Article
- Impact of hapten presentation on antibody binding at lipid membrane interfaces.Biophysical journal · 2008Article
- Monitoring receptor-ligand interactions between surfaces by thermal fluctuations.Biophysical journal · 2008Article
- Antibodies as drug carriers III: design of oligonucleotides with enhanced binding affinity for immunoglobulin G.Pharmaceutical research · 2005Article
- Enforced detachment of red blood cells adhering to surfaces: statics and dynamics.Biophysical journal · 2004Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We report observations in real time of thermally driven adhesion and dissociation between a monoclonal IgE antibody and its specific antigen N-epsilon-2,4-dinitrophenyl-L-lysine. Both molecules were attached to the surfaces of different polystyrene microspheres trapped by optical tweezers. Monitoring spontaneous successive attachment and detachment events allowed a direct determination of the reaction-limited detachment rate k(off) for a single bond and also for multiple bonds. We observed both positive and negative cooperativity between multiple bonds depending on whether the antigen was linked to the microsphere with or without a tether, respectively.
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