ArticleBiophysical journal2002
Neutrophil transit times through pulmonary capillaries: the effects of capillary geometry and fMLP-stimulation.
Article in Biophysical journal, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 84 citations in OpenAlex.
- Fluid shear stress coupled with narrow constrictions induce cell type-dependent morphological and molecular changes in SK-BR-3 and MDA-MB-231 cells.Scientific reports · 2020Article
- In vivo imaging reveals unique neutrophil transendothelial migration patterns in inflamed intestines.Mucosal immunology · 2018Article
- Nephrogenic acute respiratory distress syndrome: A narrative review on pathophysiology and treatment.Chinese journal of traumatology = Zhonghua chuang shang za zhi · 2018Review
- Characterizing cellular mechanical phenotypes with mechano-node-pore sensing.Microsystems & nanoengineering · 2018Article
- Direct Numerical Simulation of Cellular-Scale Blood Flow in 3D Microvascular Networks.Biophysical journal · 2017Article
- Quantitative Deformability Cytometry: Rapid, Calibrated Measurements of Cell Mechanical Properties.Biophysical journal · 2017Article
- Histones and Neutrophil Extracellular Traps Enhance Tubular Necrosis and Remote Organ Injury in Ischemic AKI.Journal of the American Society of Nephrology : JASN · 2017Article
- Clusters of circulating tumor cells traverse capillary-sized vessels.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Characterizing Cellular Biophysical Responses to Stress by Relating Density, Deformability, and Size.Biophysical journal · 2015Article
- Characterizing deformability and surface friction of cancer cells.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Nuclear envelope composition determines the ability of neutrophil-type cells to passage through micron-scale constrictions.The Journal of biological chemistry · 2013Article
- Single cell rheometry with a microfluidic constriction: Quantitative control of friction and fluid leaks between cell and channel walls.Biomicrofluidics · 2013Article
- Numerical simulation of passage of a neutrophil through a rectangular channel with a moderate constriction.PloS one · 2013Article
- A microfabricated deformability-based flow cytometer with application to malaria.Lab on a chip · 2011Article
- Microfluidic investigation reveals distinct roles for actin cytoskeleton and myosin II activity in capillary leukocyte trafficking.Biophysical journal · 2009Article
- Analyzing cell mechanics in hematologic diseases with microfluidic biophysical flow cytometry.Lab on a chip · 2008Article
- Mechanisms of ANCA-mediated leukocyte-endothelial cell interactions in vivo.Journal of the American Society of Nephrology : JASN · 2008Article
- Rheology of passive and adhesion-activated neutrophils probed by atomic force microscopy.Biophysical journal · 2006Article
- The mechanics of neutrophils: synthetic modeling of three experiments.Biophysical journal · 2003Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The deformations of neutrophils as they pass through the pulmonary microcirculation affect their transit time, their tendency to contact and interact with the endothelial surface, and potentially their degree of activation. Here we model the cell as a viscoelastic Maxwell material bounded by constant surface tension and simulate indentation experiments to quantify the effects of (N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP)-stimulation on its mechanical properties (elastic shear modulus and viscosity). We then simulate neutrophil transit through individual pulmonary capillary segments to determine the relative effects of capillary geometry and fMLP-stimulation on transit time. Indentation results indicate that neutrophil viscosity and shear modulus increase by factors of 3.4, for 10(-9) M fMLP, and 7.3, for 10(-6) M fMLP, over nonstimulated cell values, determined to be 30.8 Pa.s and 185 Pa, respectively. Capillary flow results indicate that capillary entrance radius of curvature has a significant effect on cell transit time, in addition to minimum capillary radius and neutrophil stimulation level. The relative effects of capillary geometry and fMLP on neutrophil transit time are presented as a simple dimensionless expression and their physiological significance is discussed.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.