ArticleBiophysical journal2002
Differential segregation in a cell-cell contact interface: the dynamics of the immunological synapse.
Article in Biophysical journal, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed.
- Amphiphilic Lipid-Single-Stranded DNA Conjugate-Mediated Cell Surface Engineering for Programmable Intercellular Tethering and Immune Synapse Formation.Biomaterials research · 2026Article
- Bayesian metamodeling of early T-cell antigen receptor signaling accounts for its nanoscale activation patterns.Frontiers in immunology · 2024Article
- Fractal dimension to characterize interactions between blood and lymphatic endothelial cells.Physical biology · 2023Article
- Simulation of receptor triggering by kinetic segregation shows role of oligomers and close contacts.Biophysical journal · 2022Article
- Spatially resolved in silico modeling of NKG2D signaling kinetics suggests a key role of NKG2D and Vav1 Co-clustering in generating natural killer cell activation.PLoS computational biology · 2022Article
- Inhibition of SHP-1 activity by PKC-θ regulates NK cell activation threshold and cytotoxicity.eLife · 2022Article
- Cooperative Stabilization of Close-Contact Zones Leads to Sensitivity and Selectivity in T-Cell Recognition.Cells · 2021Article
- System-Level Scenarios for the Elucidation of T Cell-Mediated Germinal Center B Cell Differentiation.Frontiers in immunology · 2021Review
- Understanding the Dynamics of T-Cell Activation in Health and Disease Through the Lens of Computational Modeling.JCO clinical cancer informatics · 2019Review
- In vitro reconstitution of T cell receptor-mediated segregation of the CD45 phosphatase.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Elastohydrodynamics and Kinetics of Protein Patterning in the Immunological Synapse.PLoS computational biology · 2015Article
- Three-Dimensional Gradients of Cytokine Signaling between T Cells.PLoS computational biology · 2015Article
- Direct single molecule measurement of TCR triggering by agonist pMHC in living primary T cells.eLife · 2013Article
- Article
- Mechanical modulation of receptor-ligand interactions at cell-cell interfaces.Biophysical journal · 2012Article
- Relaxation estimation of RMSD in molecular dynamics immunosimulations.Computational and mathematical methods in medicine · 2012Article
- Boltzmann energy-based image analysis demonstrates that extracellular domain size differences explain protein segregation at immune synapses.PLoS computational biology · 2011Article
- Line tension and stability of domains in cell-adhesion zones mediated by long and short receptor-ligand complexes.PloS one · 2011Article
- Monte Carlo investigation of diffusion of receptors and ligands that bind across opposing surfaces.Annals of biomedical engineering · 2011Article
- Understanding the structure and function of the immunological synapse.Cold Spring Harbor perspectives in biology · 2010Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Receptor-ligand couples in the cell-cell contact interface between a T cell and an antigen-presenting cell form distinct geometric patterns and undergo spatial rearrangement within the contact interface. Spatial segregation of the antigen and adhesion receptors occurs within seconds of contact, central aggregation of the antigen receptor then occurring over 1-5 min. This structure, called the immunological synapse, is becoming a paradigm for localized signaling. However, the mechanisms driving its formation, in particular spatial segregation, are currently not understood. With a reaction diffusion model incorporating thermodynamics, elasticity, and reaction kinetics, we examine the hypothesis that differing bond lengths (extracellular domain size) is the driving force behind molecular segregation. We derive two key conditions necessary for segregation: a thermodynamic criterion on the effective bond elasticity and a requirement for the seeding/nucleation of domains. Domains have a minimum length scale and will only spontaneously coalesce/aggregate if the contact area is small or the membrane relaxation distance large. Otherwise, differential attachment of receptors to the cytoskeleton is required for central aggregation. Our analysis indicates that differential bond lengths have a significant effect on synapse dynamics, i.e., there is a significant contribution to the free energy of the interaction, suggesting that segregation by differential bond length is important in cell-cell contact interfaces and the immunological synapse.
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