ArticleAmerican journal of human genetics2002
On the twin risk in autism.
Article in American journal of human genetics, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
36 citing papers in PubMed, 101 citations in OpenAlex.
- Thorough clinical child psychiatric diagnostic evaluation and validation of the Autism- Tics, ADHD and other comorbidities inventory (A-TAC) in a population-based sample of 9-year-olds.BMC psychiatry · 2025Article
- Socio-economic status and autism spectrum disorder: A case-control study in Bangladesh.Preventive medicine reports · 2024Article
- Infantile neurodevelopmental outcome after fetoscopic laser photocoagulation for twin-to-twin transfusion syndrome: the first prospective experience from Iran.BMC pregnancy and childbirth · 2022Article
- Pregnant Mothers' Medical Claims and Associated Risk of Their Children being Diagnosed with Autism Spectrum Disorder.Journal of personalized medicine · 2021Article
- The development of a brief screener for autism using item response theory.BMC psychiatry · 2019Article
- Physical health in children with neurodevelopmental disorders.Journal of autism and developmental disorders · 2019Article
- Heritable Variation, With Little or No Maternal Effect, Accounts for Recurrence Risk to Autism Spectrum Disorder in Sweden.Biological psychiatry · 2018Article
- The Autism-Tics, ADHD and other Comorbidities inventory (A-TAC): previous and predictive validity.BMC psychiatry · 2017Article
- Medical history of discordant twins and environmental etiologies of autism.Translational psychiatry · 2017Article
- Potential serum biomarkers from a metabolomics study of autism.Journal of psychiatry & neuroscience : JPN · 2016Article
- Interpregnancy Interval and Risk of Autism Spectrum Disorders.Pediatrics · 2015Article
- Autism phenotype versus registered diagnosis in Swedish children: prevalence trends over 10 years in general population samples.BMJ (Clinical research ed.) · 2015Article
- Common genetic variants on 1p13.2 associate with risk of autism.Molecular psychiatry · 2014Article
- Genetic diagnosis of autism spectrum disorders: the opportunity and challenge in the genomics era.Critical reviews in clinical laboratory sciences · 2014Review
- Neuroimaging endophenotypes in animal models of autism spectrum disorders: lost or found in translation?Psychopharmacology · 2014Review
- Sociability and brain development in BALB/cJ and C57BL/6J mice.Behavioural brain research · 2012Article
- Have secular changes in perinatal risk factors contributed to the recent autism prevalence increase? Development and application of a mathematical assessment model.Annals of epidemiology · 2011Article
- Multiple autism-like behaviors in a novel transgenic mouse model.Behavioural brain research · 2011Article
- Overlaps between autism and language impairment: phenomimicry or shared etiology?Behavior genetics · 2010Article
- Immune therapy in autism: historical experience and future directions with immunomodulatory therapy.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2010Review
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Autism is considered by many to be the most strongly genetically influenced multifactorial childhood psychiatric disorder. In the absence of any known gene or genes, the main support for this is derived from family and twin studies. Two recent studies (Greenberg et al. 2001; Betancur et al. 2002) suggested that the twinning process itself is an important risk factor in the development of autism. If true, this would have major consequences for the interpretation of twin studies. Both studies compared the number of affected twin pairs among affected sib pairs to expected values in two separate samples of multiplex families and reported a substantial and significant excess of twin pairs. Using data from our epidemiological study in Western Australia, we investigated the possibility of an increased rate of autism in twins. All children born between 1980 and 1995 with autism, Asperger syndrome, or pervasive developmental disorder not otherwise specified (PDD-NOS) were ascertained. Of the 465 children with a diagnosis, 14 were twin births (rate 30.0/1,000) compared to 9,640 children of multiple births out of a total of 386,637 births in Western Australia between 1980 and 1995 (twin rate weighted to number of children with autism or PDD per year 26.3/1,000). These data clearly do not support twinning as a substantial risk factor in the etiology of autism. We demonstrate that the high proportion of twins found in affected-sib-pair studies can be adequately explained by the high ratio of concordance rates in monozygotic (MZ) twins versus siblings and the distribution of family size in the population studied. Our results are in agreement with those of two similar studies by Croen et al. (2002) in California and Hultman et al. (2002) in Sweden.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.