ArticleWorld journal of surgery2002
Functional and morphologic properties of a modified mesh for inguinal hernia repair.
Article in World journal of surgery, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 1 synthesis or guideline pooled it, 164 citations in OpenAlex.
- Meta-analysis of randomized controlled trials comparing lightweight and heavyweight mesh for Lichtenstein inguinal hernia repair.Hernia : the journal of hernias and abdominal wall surgery · 2012Pooled it
- Randomized clinical trial comparing lightweight mesh with heavyweight mesh for primary inguinal hernia repair.Hernia : the journal of hernias and abdominal wall surgery · 2013Trial
- Chronic pain after laparoscopic transabdominal preperitoneal hernia repair: a randomized comparison of light and extralight titanized polypropylene mesh.World journal of surgery · 2011Trial
- Sixty-month follow-up after endoscopic inguinal hernia repair with three types of mesh: a prospective randomized trial.Surgical endoscopy · 2008Trial
- Early results of a randomised trial comparing Prolene and VyproII-mesh in endoscopic extraperitoneal inguinal hernia repair (TEP) of recurrent unilateral hernias.Hernia : the journal of hernias and abdominal wall surgery · 2006Trial
- One year results of a randomised controlled multi-centre study comparing Prolene and Vypro II-mesh in Lichtenstein hernioplasty.Hernia : the journal of hernias and abdominal wall surgery · 2005Trial
- Early results of a randomized multicenter trial comparing Prolene and VyproII mesh in bilateral endoscopic extraperitoneal hernioplasty (TEP).Surgical endoscopy · 2005Trial
- Early results of a single-blinded, randomized, controlled, Internet-based multicenter trial comparing Prolene and Vypro II mesh in Lichtenstein hernioplasty.Hernia : the journal of hernias and abdominal wall surgery · 2004Trial
- Assessing the Impact of Morphological Parameters on the Mechanical Behavior of Synthetic Meshes. A Multivariate Regression Approach.International journal for numerical methods in biomedical engineering · 2025Article
- Objective follow-up after transection of uterine round ligament during laparoscopic repair of inguinal hernias in women: assessment of safety and long-term outcomes.Surgical endoscopy · 2022Article
- Rabbit as an animal model for the study of biological grafts in pelvic floor dysfunctions.Scientific reports · 2021Article
- Does a bilateral polypropylene mesh alter the duct deferens morphology, testicular size and testosterone levels? Experimental study in rats.Acta cirurgica brasileira · 2020Article
- Lower recurrence rate with heavyweight mesh compared to lightweight mesh in laparoscopic totally extra-peritoneal (TEP) repair of groin hernia: a nationwide population-based register study.Hernia : the journal of hernias and abdominal wall surgery · 2018Article
- Chronic pain, discomfort, quality of life and impact on sex life after open inguinal hernia mesh repair: an expertise-based randomized clinical trial comparing lightweight and heavyweight mesh.Hernia : the journal of hernias and abdominal wall surgery · 2018Article
- Design Strategies and Applications of Biomaterials and Devices for Hernia Repair.Bioactive materials · 2016Article
- Location of recurrent groin hernias at TEP after Lichtenstein repair: a study based on the Swedish Hernia Register.Hernia : the journal of hernias and abdominal wall surgery · 2016Article
- In vivo characterisation of the inflammatory reaction following mesh implantation in transgenic mice models.Langenbeck's archives of surgery · 2014Article
- Comparative study of shrinkage, inflammatory response and fibroplasia in heavyweight and lightweight meshes.Hernia : the journal of hernias and abdominal wall surgery · 2013Article
- Inflammatory reaction and neotissue maturation in the early host tissue incorporation of polypropylene prostheses.Hernia : the journal of hernias and abdominal wall surgery · 2012Article
- A comparison of two types of preperitoneal mesh prostheses in stoma surgery: application to an animal model.Hernia : the journal of hernias and abdominal wall surgery · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Inguinal hernia repair is one of the most frequently performed operations. Next to conventional techniques, open and laparoscopic tension-free methods using mesh implants to reinforce the abdominal wall are increasingly carried out, even becoming the standard procedure in many countries. Because of the benefits of material-reduced meshes for incisional hernia repair, a new mesh modification for tension-free inguinal hernia repair has been developed. In the present study this new low-weight mesh (Vypro II) made of polypropylene and polyglactin multifilaments was compared to a common heavy-weight polypropylene mesh (Prolene) regarding their functional consequences and the morphologic tissue response. After implantation in rats as an inlay, abdominal wall mobility was recorded by three-dimensional photogrammetry and the tensile strength of the suture zone and the mesh itself was measured at 3, 21, and 90 days. Explanted tissue samples have been investigated for their histologic reaction in regard to the inflammatory infiltrate, vascularization, and connective and fat tissue ingrowth. Numbers of granulocytes, macrophages, fibroblasts, lymphocytes, and foreign giant body cells have been evaluated to reflect the quality of the tissue response. The cellular response was assessed by measuring DNA strand breaks and apoptosis (TUNEL), proliferation (Ki67), and cell stress (HSP70). The results indicated that restriction of abdominal wall mobility was significantly reduced with Vypro II compared to that seen with heavy-weight mesh modification, and the inflammatory reaction and connective tissue formation were markedly diminished. Apoptosis and cell proliferation showed considerably lowered levels, and expression of cytoprotective HSP70 was significantly increased. The present study thus confirms the benefits of material-reduced mesh modifications. The new low-weight mesh (Vypro II) could be advantageous in inguinal hernia repair.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.