ArticleProceedings of the National Academy of Sciences of the United States of America2002
Alpha-fetoprotein, the major fetal serum protein, is not essential for embryonic development but is required for female fertility.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
43 citing papers in PubMed, 112 citations in OpenAlex.
- Exploring the Multifunctional Role of Alpha-Fetoprotein in Cancer Progression: Implications for Targeted Therapy in Hepatocellular Carcinoma and Beyond.International journal of molecular sciences · 2025Review
- Potential contribution of alpha-fetoprotein level to biomarker of pregnancy outcome in Asian elephants.Veterinary medicine and science · 2024Article
- AFP-HSP90 mediated MYC/MET activation promotes tumor progression in hepatocellular carcinoma and gastric cancers.Cancer cell international · 2024Article
- A framework for identifying fertility gene targets for mammalian pest control.Molecular ecology resources · 2024Article
- A Novel Cell-Based Model for a Rare Disease: The Tks4-KO Human Embryonic Stem Cell Line as a Frank-Ter Haar Syndrome Model System.International journal of molecular sciences · 2022Article
- Insights into in vivo follicle formation: a review of in vitro systems.Histochemistry and cell biology · 2022Review
- Targeted whole exome sequencing and Drosophila modelling to unveil the molecular basis of primary ovarian insufficiency.Human reproduction (Oxford, England) · 2021Article
- Blocking estrogen-induced AMH expression is crucial for normal follicle formation.Development (Cambridge, England) · 2021Article
- AFP promotes HCC progression by suppressing the HuR-mediated Fas/FADD apoptotic pathway.Cell death & disease · 2020Article
- Proteomic Analysis of Charcoal-Stripped Fetal Bovine Serum Reveals Changes in the Insulin-like Growth Factor Signaling Pathway.Journal of proteome research · 2018Article
- Article
- Vascular and Immunobiology of the Circulatory Sphingosine 1-Phosphate Gradient.Annual review of physiology · 2017Review
- Circulating predictive and diagnostic biomarkers for hepatitis B virus-associated hepatocellular carcinoma.World journal of gastroenterology · 2016Review
- Genome-wide association and identification of candidate genes for age at puberty in swine.BMC genetics · 2016Article
- 2D DIGE proteomic analysis highlights delayed postnatal repression of α-fetoprotein expression in homocystinuria model mice.FEBS open bio · 2015Article
- Albuminoid genes: evolving at the interface of dispensability and selection.Genome biology and evolution · 2014Article
- A comparative analysis of synonymous codon usage bias pattern in human albumin superfamily.TheScientificWorldJournal · 2014Article
- Article
- Alpha-fetoprotein: a renaissance.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2013Review
- Characterization of alpha-fetoprotein levels in three dolphin species: development of sensitive immunoassays for analysis of the pregnancy-associated variations.The Journal of reproduction and development · 2013Article
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The alpha-fetoprotein gene (Afp) is a member of a multigenic family that comprises the related genes encoding albumin, alpha-albumin, and vitamin D binding protein. The biological role of this major embryonic serum protein is unknown although numerous speculations have been made. We have used gene targeting to show that AFP is not required for embryonic development. AFP null embryos develop normally, and individually transplanted homozygous embryos can develop in an AFP-deficient microenvironment. Whereas mutant homozygous adult males are viable and fertile, AFP null females are infertile. Our analyses of these mice indicate that the defect is caused by a dysfunction of the hypothalamic/pituitary system, leading to anovulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.