ArticleClinical and experimental immunology2002
X-chromosome inactivation analysis in a female carrier of FOXP3 mutation.
Article in Clinical and experimental immunology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 97 citations in OpenAlex.
- Reduced mouse allergen is associated with epigenetic changes in regulatory genes, but not mouse sensitization, in asthmatic children.Environmental research · 2017Trial
- Review
- Sex differences in disease: sex chromosome and immunity.Journal of translational medicine · 2024Review
- Role of sex in immune response and epigenetic mechanisms.Epigenetics & chromatin · 2024Review
- Identification of unstable regulatory and autoreactive effector T cells that are expanded in patients withScience translational medicine · 2023Article
- Lung tumor-infiltrating TScience immunology · 2023Article
- Characterization of human epithelial resident memory regulatory T cells.Frontiers in immunology · 2022Article
- Immunity and Genetics at the Revolving Doors of Diagnostics in Primary Immunodeficiencies.Diagnostics (Basel, Switzerland) · 2021Article
- Sex and FOXP3 gene rs2232365 polymorphism may be associated with the clinical and pathological aspects of chronic viral diseases.BMC immunology · 2020Article
- What's Sex Got to Do With COVID-19? Gender-Based Differences in the Host Immune Response to Coronaviruses.Frontiers in immunology · 2020Review
- Enumerating regulatory T cells in cryopreserved umbilical cord blood samples using FOXP3 methylation specific quantitative PCR.PloS one · 2020Article
- Bcl10-controlled Malt1 paracaspase activity is key for the immune suppressive function of regulatory T cells.Nature communications · 2019Article
- Differential gene expression in human tissue resident regulatory T cells from lung, colon, and blood.Oncotarget · 2018Article
- Regulatory T cells induced by B cells: a novel subpopulation of regulatory T cells.Journal of biomedical science · 2017Review
- Novel pathogenic variants in FOXP3 in fetuses with echogenic bowel and skin desquamation identified by ultrasound.American journal of medical genetics. Part A · 2017Article
- FOXP3(+) Treg Cells and Gender Bias in Autoimmune Diseases.Frontiers in immunology · 2015Review
- Short stature in child with early-onset diabetes.European journal of pediatrics · 2013Article
- Proliferative vitreoretinopathy may be a risk factor in combined macular hole retinal detachment cases.Retina (Philadelphia, Pa.) · 2013Article
- The clinical utility of molecular diagnostic testing for primary immune deficiency disorders: a case based review.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2010Article
- X-linked tumor suppressors: perplexing inheritance, a unique therapeutic opportunity.Trends in genetics : TIG · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Immune dysregulation, polyendocrinopathy and enteropathy with X-linked inheritance (IPEX) is a serious disease arising from mutations in FOXP3. This gene codifies for a transcription factor whose dysfunction results in hyperactivation of T cells. It is not clear, however, why an intermediate phenotype is not seen in heterozygous females, who are completely healthy. In order to address this question, we investigated X-chromosome inactivation in peripheral blood lymphocytes from a heterozygous female with a child affected by IPEX. No preferential inactivation was shown in freshly sorted CD4+, CD8+, CD19+ cells or in IL-2 cultured CD4 and CD8 T cells, indicating that peripheral blood lymphocytes in these women are randomly selected. Moreover, only one single FOXP3 transcript was expressed by CD4 T cell clones analysed by RT-PCR, confirming that this gene is subject to X- inactivation. We hypothesize that hyper-activation of T cell in carriers of FOXP3 mutations is regulated by the presence of normal regulatory T cells.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.