ArticleProceedings of the National Academy of Sciences of the United States of America2002
Pipsqueak and GAGA factor act in concert as partners at homeotic and many other loci.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 79 citations in OpenAlex.
- Polycomb Group Proteins inBiology · 2026Review
- Looping specificity of Polycomb response elements requires GAF and a combination of looping factors that could form a code.Nucleic acids research · 2026Article
- Context-dependent role of Pho binding sites in Polycomb complex recruitment in Drosophila.Genetics · 2023Article
- Polycomb Recruiters Inside and Outside of the Repressed Domains.International journal of molecular sciences · 2023Review
- GAGA-associated factor fosters loop formation in the Drosophila genome.Molecular cell · 2023Article
- Distinct roles for canonical and variant histone H3 lysine-36 in Polycomb silencing.Science advances · 2023Article
- Kinetic principles underlying pioneer function of GAGA transcription factor in live cells.Nature structural & molecular biology · 2022Article
- Comparative interactome analysis of the PRE DNA-binding factors: purification of the Combgap-, Zeste-, Psq-, and Adf1-associated proteins.Cellular and molecular life sciences : CMLS · 2022Article
- GAGA factor: a multifunctional pioneering chromatin protein.Cellular and molecular life sciences : CMLS · 2021Review
- Ecdysone-Induced 3D Chromatin Reorganization Involves Active Enhancers Bound by Pipsqueak and Polycomb.Cell reports · 2019Article
- Global changes of H3K27me3 domains and Polycomb group protein distribution in the absence of recruiters Spps or Pho.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Polycomb and Trithorax Group Genes inGenetics · 2017Review
- The GAGA factor regulatory network: Identification of GAGA factor associated proteins.PloS one · 2017Article
- 20-Hydroxyecdysone (20E) Primary Response Gene E93 Modulates 20E Signaling to Promote Bombyx Larval-Pupal Metamorphosis.The Journal of biological chemistry · 2015Article
- GAGA factor maintains nucleosome-free regions and has a role in RNA polymerase II recruitment to promoters.PLoS genetics · 2015Article
- What are memories made of? How Polycomb and Trithorax proteins mediate epigenetic memory.Nature reviews. Molecular cell biology · 2014Review
- Are we there yet? Initial targeting of the Male-Specific Lethal and Polycomb group chromatin complexes in Drosophila.Open biology · 2014Review
- Male-specific fruitless isoforms target neurodevelopmental genes to specify a sexually dimorphic nervous system.Current biology : CB · 2014Article
- High-resolution mapping of transcription factor binding sites on native chromatin.Nature methods · 2014Article
- Mitotic bookmarking by transcription factors.Epigenetics & chromatin · 2013Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Drosophila GAGA factor (GAF) controls transcription and other chromosome functions by altering chromatin structure. We found that a second GAGA-binding protein of Drosophila, Pipsqueak (Psq), can directly bind to GAF and is associated with GAF in vivo. Genetic interaction studies provide evidence that Psq and GAF act together in the transcriptional activation and silencing of homeotic genes. A complete colocalization of Psq and GAF on polytene interphase chromosomes and mitotic chromosomes suggests that the two proteins cooperate as general partners not only at homeotic loci, but also at hundreds of other chromosomal sites.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.