ArticleProceedings of the National Academy of Sciences of the United States of America2002
An activation domain in the C-terminal subunit of HCF-1 is important for transactivation by VP16 and LZIP.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 44 citations in OpenAlex.
- The opportunities and challenges of epigenetic approaches to manage herpes simplex infections.Expert review of anti-infective therapy · 2024Review
- Article
- The role of HCFC1 in syndromic and non-syndromic intellectual disability.Medical research archives · 2020Article
- The Role of VP16 in the Life Cycle of Alphaherpesviruses.Frontiers in microbiology · 2020Review
- HCF1 and OCT2 Cooperate with EBNA1 To Enhance OriP-Dependent Transcription and Episome Maintenance of Latent Epstein-Barr Virus.Journal of virology · 2016Article
- A comparison of herpes simplex virus type 1 and varicella-zoster virus latency and reactivation.The Journal of general virology · 2015Review
- Probing of the nuclear import and export signals and subcellular transport mechanism of varicella-zoster virus tegument protein open reading frame 10.Medical microbiology and immunology · 2012Article
- HDAC3 selectively represses CREB3-mediated transcription and migration of metastatic breast cancer cells.Cellular and molecular life sciences : CMLS · 2010Article
- The deubiquitinating enzyme BAP1 regulates cell growth via interaction with HCF-1.The Journal of biological chemistry · 2009Article
- Krox20 controls the transcription of its various targets in the developing hindbrain according to multiple modes.The Journal of biological chemistry · 2009Article
- Association of the cellular coactivator HCF-1 with the Golgi apparatus in sensory neurons.Journal of virology · 2008Article
- A novel protein, Luman/CREB3 recruitment factor, inhibits Luman activation of the unfolded protein response.Molecular and cellular biology · 2008Article
- Species selectivity of mixed-lineage leukemia/trithorax and HCF proteolytic maturation pathways.Molecular and cellular biology · 2007Article
- The coactivator host cell factor-1 mediates Set1 and MLL1 H3K4 trimethylation at herpesvirus immediate early promoters for initiation of infection.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Host cell factor-1 and E2F4 interact via multiple determinants in each protein.Molecular and cellular biochemistry · 2006Article
- Site-specific proteolysis of the transcriptional coactivator HCF-1 can regulate its interaction with protein cofactors.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Varicella-zoster virus open reading frame 10 is a virulence determinant in skin cells but not in T cells in vivo.Journal of virology · 2006Article
- The neuronal host cell factor-binding protein Zhangfei inhibits herpes simplex virus replication.Journal of virology · 2005Article
- Herpes simplex virus infections are arrested in Oct-1-deficient cells.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- HCF-1 functions as a coactivator for the zinc finger protein Krox20.The Journal of biological chemistry · 2003Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
In herpes simplex virus, lytic replication is initiated by the viral transactivator VP16 acting with cellular cofactors Oct-1 and HCF-1. Although this activator complex has been studied in detail, the role of HCF-1 remains elusive. Here, we show that HCF-1 contains an activation domain (HCF-1(AD)) required for maximal transactivation by VP16 and its cellular counterpart LZIP. Expression of the VP16 cofactor p300 augments HCF-1(AD) activity, suggesting a mechanism of synergy. Infection of cells lacking the HCF-1(AD) leads to reduced viral immediate-early gene expression and lowered viral titers. These findings underscore the importance of HCF-1 to herpes simplex virus replication and VP16 transactivation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.