ArticleJournal of bacteriology2002
A CheW homologue is required for Myxococcus xanthus fruiting body development, social gliding motility, and fibril biogenesis.
Article in Journal of bacteriology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Article
- Analysis of CheW-like domains provides insights into organization of prokaryotic chemotaxis systems.Proteins · 2023Article
- Analysis ofFrontiers in microbiology · 2022Article
- Direct interaction between RecA and a CheW-like protein is required for surface-associated motility, chemotaxis and the full virulence ofVirulence · 2020Article
- Characterization of the Exopolysaccharide Biosynthesis Pathway in Myxococcus xanthus.Journal of bacteriology · 2020Article
- Article
- The Two Chemotaxis Clusters in Caulobacter crescentus Play Different Roles in Chemotaxis and Biofilm Regulation.Journal of bacteriology · 2019Article
- Article
- Cellular responses during morphological transformation in Azospirillum brasilense and Its flcA knockout mutant.PloS one · 2014Article
- DifA, a methyl-accepting chemoreceptor protein-like sensory protein, uses a novel signaling mechanism to regulate exopolysaccharide production in Myxococcus xanthus.Journal of bacteriology · 2011Article
- Article
- Phosphorylation and dephosphorylation among Dif chemosensory proteins essential for exopolysaccharide regulation in Myxococcus xanthus.Journal of bacteriology · 2010Article
- Developments in Defining dif.Journal of bacteriology · 2010Article
- Isolation and characterization of a suppressor mutation that restores Myxococcus xanthus exopolysaccharide production.Microbiology (Reading, England) · 2009Article
- Function of a chemotaxis-like signal transduction pathway in modulating motility, cell clumping, and cell length in the alphaproteobacterium Azospirillum brasilense.Journal of bacteriology · 2008Article
- Independence and interdependence of Dif and Frz chemosensory pathways in Myxococcus xanthus chemotaxis.Molecular microbiology · 2008Article
- The mosaic genome of Anaeromyxobacter dehalogenans strain 2CP-C suggests an aerobic common ancestor to the delta-proteobacteria.PloS one · 2008Article
- Subcellular location characteristics of the Pseudomonas aeruginosa GGDEF protein, WspR, indicate that it produces cyclic-di-GMP in response to growth on surfaces.Molecular microbiology · 2007Article
- Proteins associated with the Myxococcus xanthus extracellular matrix.Journal of bacteriology · 2007Article
- The orphan response regulator DigR is required for synthesis of extracellular matrix fibrils in Myxococcus xanthus.Journal of bacteriology · 2006Article
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Authors and funding
4 authors.
Funding
Abstract
In bacteria with multiple sets of chemotaxis genes, the deletion of homologous genes or even different genes in the same operon can result in disparate phenotypes. Myxococcus xanthus is a bacterium with multiple sets of chemotaxis genes and/or homologues. It was shown previously that difA and difE, encoding homologues of the methyl-accepting chemoreceptor protein (MCP) and the CheA kinase, respectively, are required for M. xanthus social gliding (S) motility and development. Both difA and difE mutants were also defective in the biogenesis of the cell surface appendages known as extracellular matrix fibrils. In this study, we investigated the roles of the CheW homologue encoded by difC, a gene at the same locus as difA and difE. We showed that difC mutations resulted in defects in M. xanthus developmental aggregation, sporulation, and S motility. We demonstrated that difC is indispensable for wild-type cellular cohesion and fibril biogenesis but not for pilus production. We further illustrated the ectopic complementation of a difC in-frame deletion by a wild-type difC. The identical phenotypes of difA, difC, and difE mutants are consistent and supportive of the hypothesis that the Dif chemotaxis homologues constitute a chemotaxis-like signal transduction pathway that regulates M. xanthus fibril biogenesis and S motility.
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