ArticleProceedings of the National Academy of Sciences of the United States of America2002
Cell transplantation after oxidative hepatic preconditioning with radiation and ischemia-reperfusion leads to extensive liver repopulation.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed.
- Stereo-cell deciphers the spatial and functional heterogeneity of polyploid hepatocytes.GigaScience · 2026Article
- Cell competition in primary and metastatic colorectal cancer.Oncogenesis · 2024Review
- Cellular polyploidy in organ homeostasis and regeneration.Protein & cell · 2023Article
- Functional characterization of CD49fJournal of molecular histology · 2022Article
- Decellularized bovine placentome for portacavally-interposed heterotopic liver transplantation in rats.Materials science & engineering. C, Materials for biological applications · 2019Article
- Hepatocyte Transplantation: Quo Vadis?International journal of radiation oncology, biology, physics · 2019Review
- The history and use of human hepatocytes for the treatment of liver diseases: the first 100 patients.Current protocols in toxicology · 2014Article
- Ischemic preconditioning affects long-term cell fate through DNA damage-related molecular signaling and altered proliferation.The American journal of pathology · 2014Article
- Bone marrow-derived stromal cell therapy in cirrhosis: clinical evidence, cellular mechanisms, and implications for the treatment of hepatocellular carcinoma.International journal of radiation oncology, biology, physics · 2014Article
- Stem cell therapies for the treatment of radiation-induced normal tissue side effects.Antioxidants & redox signaling · 2014Review
- Transplantation of ATP7B-transduced bone marrow mesenchymal stem cells decreases copper overload in rats.PloS one · 2014Article
- Early stage transplantation of bone marrow cells markedly ameliorates copper metabolism and restores liver function in a mouse model of Wilson disease.BMC gastroenterology · 2011Article
- Model systems and experimental conditions that lead to effective repopulation of the liver by transplanted cells.The international journal of biochemistry & cell biology · 2011Review
- Human hepatocyte transplantation: current experience and future challenges.Nature reviews. Gastroenterology & hepatology · 2010Review
- Bile salt-induced pro-oxidant liver damage promotes transplanted cell proliferation for correcting Wilson disease in the Long-Evans Cinnamon rat model.Hepatology (Baltimore, Md.) · 2009Article
- Epigenetic reprogramming of IGF1 and leptin genes by serum deprivation in multipotential mesenchymal stromal cells.Stem cells (Dayton, Ohio) · 2009Article
- Liver repopulation and carcinogenesis: two sides of the same coin?The American journal of pathology · 2008Review
- Liver cirrhosis.Lancet (London, England) · 2008Review
- Physiological variations of stem cell factor and stromal-derived factor-1 in murine models of liver injury and regeneration.Liver international : official journal of the International Association for the Study of the Liver · 2008Article
- Stem cells, cell transplantation and liver repopulation.Biochimica et biophysica acta · 2008Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The inability of transplanted cells to proliferate in the normal liver hampers cell therapy. We considered that oxidative hepatic DNA damage would impair the survival of native cells and promote proliferation in transplanted cells. Dipeptidyl peptidase-deficient F344 rats were preconditioned with whole liver radiation and warm ischemia-reperfusion followed by intrasplenic transplantation of syngeneic F344 rat hepatocytes. The preconditioning was well tolerated, although serum aminotransferase levels rose transiently and hepatic injury was observed histologically, along with decreased catalase activity and 8-hydroxy adducts of guanine, indicating oxidative DNA damage. Transplanted cells did not proliferate in the liver over 3 months in control animals and animals preconditioned with ischemia-reperfusion alone. Animals treated with radiation alone showed some transplanted cell proliferation. In contrast, the liver of animals preconditioned with radiation plus ischemia-reperfusion was replaced virtually completely over 3 months. Transplanted cells integrated in the liver parenchyma and liver architecture were preserved normally. These findings offer a paradigm for repopulating the liver with transplanted cells. Progressive loss of cells experiencing oxidative DNA damage after radiation and ischemia-reperfusion injury could be of significance for epithelial renewal in additional organs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.