ArticleArchives of disease in childhood2002
Thyroid hormones before and after weight loss in obesity.
Article in Archives of disease in childhood, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00871130 (The Effect of Bariatric Surgery on Thyroid Function and Morphology, a Retrospective Study), which is not on this map. Cited by 55 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Bariatric Surgery on Thyroid Function and Morphology, a Retrospective Study
Who cites it
55 citing papers in PubMed, 1 synthesis or guideline pooled it, 190 citations in OpenAlex.
- Genome-wide association meta-analysis for total thyroid hormone levels in Croatian population.Journal of human genetics · 2019Pooled it
- Changes in lifestyle improve body composition, thyroid function, and structure in obese children.Journal of endocrinological investigation · 2012Trial
- Combined Treatment of Type 2 Diabetes and Hypothyroidism: Impact of Oral Semaglutide and Levothyroxine on Cardiometabolic and Thyroid Parameters: A 6-Month Comparative Study.Epidemiologia (Basel, Switzerland) · 2026Article
- Does Bariatric Surgery Impact Hypothyroidism and Vice Versa? Results of a Prospective Comparative Study.Obesity surgery · 2025Article
- Obesity-related subclinical hypothyroidism in childhood: Elevated triglycerides but not basal metabolic rate.Pediatric research · 2025Article
- The impact of weight loss interventions on thyroid function: a systematic review and meta-analysis.Annals of medicine and surgery (2012) · 2025Review
- Investigation of the effects of laparoscopic sleeve gastrectomy and laparoscopic one anastomosis gastric bypass on metabolic syndrome components.BMC surgery · 2025Article
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- Article
- Nutrient and Hormonal Effects on Long Bone Growth in Healthy and Obese Children: A Literature Review.Children (Basel, Switzerland) · 2024Review
- Longitudinal analysis of epigenome-wide DNA methylation reveals novel loci associated with BMI change in East Asians.Clinical epigenetics · 2024Article
- Total weight loss induces the alteration in thyroid function after bariatric surgery.Frontiers in endocrinology · 2024Article
- Insulin Resistance and Hypertension: Mechanisms Involved and Modifying Factors for Effective Glucose Control.Biomedicines · 2023Review
- Thyroid dysfunction in children and adolescents affected by undernourished and overnourished eating disorders.Frontiers in nutrition · 2023Review
- Thyroid Function Alteration in Obesity and the Effect of Bariatric Surgery.Journal of clinical medicine · 2022Review
- Thyroid axis hormones and anthropometric recovery of children/adolescents with overweight/obesity: A scoping review.Frontiers in nutrition · 2022Article
- Impact of Weight Reduction on Thyroid Function and Nonalcoholic Fatty Liver among Egyptian Adolescents with Obesity.International journal of endocrinology · 2022Article
- Basal and longitudinal changes in serum levels of TSH in morbid obese patients experiencing failure or success of dietary treatment.Eating and weight disorders : EWD · 2021Article
- Subclinical hypothyroidism in children: updates for pediatricians.Annals of pediatric endocrinology & metabolism · 2021Article
- Central Resistance to Thyroid Hormones in Morbidly Obese Subjects Is Reversed after Bariatric Surgery-Induced Weight Loss.Journal of clinical medicine · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLittle is known about changes in thyroid function in obese children. An influence of leptin on thyroid hormone synthesis has been proposed.
aimsTo examine thyroid function and leptin concentrations in obese children.
methodsTriiodothyronine (T3), thyroxine (T4), thyroid stimulating hormone (TSH), and leptin were measured in 118 obese children (aged 4.5-16 years); thyroid function was also determined in 107 healthy children of normal weight. T3, T4, and TSH were analysed in 55 obese children who had achieved weight reduction and in 13 obese children who had not achieved weight reduction after one year based on normal energy diet.
resultsTSH, T3, and T4 were significantly higher in obese children compared to those of normal weight. Twelve per cent of the obese children had TSH, 15% had T3, and 11% had T4 concentrations above the twofold standard deviation of normal weight children. The degree of overweight correlated with T3, T4, and TSH. Thyroid hormones did not correlate significantly with leptin. A reduction in overweight showed a significant decrease in T3, T4, and leptin serum concentrations, but there was no significant change in TSH.
conclusionPeripheral thyroid hormones (T3, T4) and TSH are moderately increased in obese children; weight reduction leads to a long term decrease in the peripheral thyroid hormones but not in TSH. There is no necessity to treat the increased serum TSH.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.