ArticleMolecular and cellular biology2002
Structural basis for activation of fibroblast growth factor signaling by sucrose octasulfate.
Article in Molecular and cellular biology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 58 citations in OpenAlex.
- Glycosaminoglycans in tissue regeneration: Insights into glycobiology and their biomedical application.Bioactive materials · 2026Review
- A double-network porous hydrogel based on high internal phase emulsions as a vehicle for potassium sucrose octasulfate delivery accelerates diabetic wound healing.Regenerative biomaterials · 2024Article
- Article
- Comparison of topical sucralfate with dexpanthenol in rat wound model.International journal of experimental pathology · 2022Article
- Synthetic polymers as xeno-free materials for stabilizing basic fibroblast growth factor in human mesenchymal stem cell cultures.Biochemistry and biophysics reports · 2021Article
- Heparin Binding Proteins as Therapeutic Target: An Historical Account and Current Trends.Medicines (Basel, Switzerland) · 2019Review
- A Detailed Protocol for Large-scale Recombinant Expression and Validation of Human FGFR2 with Its Transmembrane and Extracellular Domains inBio-protocol · 2019Article
- Recombinant expression inPeerJ · 2017Article
- Article
- Article
- Structural and functional characterization of DUF1471 domains of Salmonella proteins SrfN, YdgH/SssB, and YahO.PloS one · 2014Article
- Activity of hypertonic solution with Silver and Potassium Sucrose Octasulfate on nasal symptoms in obstructive rhinopathy with and without rhinosinusitis.SpringerPlus · 2013Article
- Molecular basis for the Kallmann syndrome-linked fibroblast growth factor receptor mutation.Biochemical and biophysical research communications · 2012Article
- A novel mechanism of osmosensing, a salt-dependent protein-nucleic acid interaction in the cyanobacterium Synechocystis Species PCC 6803.The Journal of biological chemistry · 2011Article
- Effects of temperature and additives on stability and spectrum of a therapeutic fibroblast growth factor.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2011Article
- NF449 is a novel inhibitor of fibroblast growth factor receptor 3 (FGFR3) signaling active in chondrocytes and multiple myeloma cells.The Journal of biological chemistry · 2010Article
- Sucrose octasulfate selectively accelerates thrombin inactivation by heparin cofactor II.The Journal of biological chemistry · 2010Article
- Dimerization effect of sucrose octasulfate on rat FGF1.Acta crystallographica. Section F, Structural biology and crystallization communications · 2008Article
- Sucrose octasulfate regulates fibroblast growth factor-2 binding, transport, and activity: potential for regulation of tumor growth.Journal of cellular physiology · 2008Article
- Parathyroid hormone is a heparin/polyanion binding protein: binding energetics and structure modification.Protein science : a publication of the Protein Society · 2007Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
Abstract
Sucrose octasulfate (SOS) is believed to stimulate fibroblast growth factor (FGF) signaling by binding and stabilizing FGFs. In this report, we show that SOS induces FGF-dependent dimerization of FGF receptors (FGFRs). The crystal structure of the dimeric FGF2-FGFR1-SOS complex at 2.6-A resolution reveals a symmetric assemblage of two 1:1:1 FGF2-FGFR1-SOS ternary complexes. Within each ternary complex SOS binds to FGF and FGFR and thereby increases FGF-FGFR affinity. SOS also interacts with the adjoining FGFR and thereby promotes protein-protein interactions that stabilize dimerization. This structural finding is supported by the inability of selectively desulfated SOS molecules to promote receptor dimerization. Thus, we propose that SOS potentiates FGF signaling by imitating the dual role of heparin in increasing FGF-FGFR affinity and promoting receptor dimerization. Hence, the dimeric FGF-FGFR-SOS structure substantiates the recently proposed "two-end" model, by which heparin induces FGF-FGFR dimerization. Moreover, the FGF-FGFR-SOS structure provides an attractive template for the development of easily synthesized SOS-related heparin agonists and antagonists that may hold therapeutic potential.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.