ArticleMolecular and cellular biology2002
The mal2p protein is an essential component of the fission yeast centromere.
Article in Molecular and cellular biology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 35 citations in OpenAlex.
- Inositol Pyrophosphate-Controlled Kinetochore Architecture and Mitotic Entry inJournal of fungi (Basel, Switzerland) · 2022Article
- Perturbation of kinetochore function using GFP-binding protein in fission yeast.G3 (Bethesda, Md.) · 2021Article
- Negative Regulation of the Mis17-Mis6 Centromere Complex by mRNA Decay Pathway and EKC/KEOPS Complex inG3 (Bethesda, Md.) · 2019Article
- Combinatorial, site-specific requirement for heterochromatic silencing factors in the elimination of nucleosome-free regions.Genes & development · 2010Article
- A high-resolution map of nucleosome positioning on a fission yeast centromere.Genome research · 2008Article
- Plasticity of fission yeast CENP-A chromatin driven by relative levels of histone H3 and H4.PLoS genetics · 2007Article
- The conserved Spc7 protein is required for spindle integrity and links kinetochore complexes in fission yeast.Molecular biology of the cell · 2007Article
- Article
- Reconstruction of the kinetochore during meiosis in fission yeast Schizosaccharomyces pombe.Molecular biology of the cell · 2006Article
- Fta2, an essential fission yeast kinetochore component, interacts closely with the conserved Mal2 protein.Molecular biology of the cell · 2006Article
- Molecular analysis of kinetochore architecture in fission yeast.The EMBO journal · 2005Article
- The role of heterochromatin in centromere function.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2005Review
- The CHD remodeling factor Hrp1 stimulates CENP-A loading to centromeres.Nucleic acids research · 2005Article
- BAF53/Arp4 homolog Alp5 in fission yeast is required for histone H4 acetylation, kinetochore-spindle attachment, and gene silencing at centromere.Molecular biology of the cell · 2005Article
- The fission yeast kinetochore component Spc7 associates with the EB1 family member Mal3 and is required for kinetochore-spindle association.Molecular biology of the cell · 2004Article
- The Schizosaccharomyces pombe HIRA-like protein Hip1 is required for the periodic expression of histone genes and contributes to the function of complex centromeres.Molecular and cellular biology · 2004Article
- The roles of histone modifications and small RNA in centromere function.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2004Review
- Kinetochore and heterochromatin domains of the fission yeast centromere.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2004Review
- Sim4: a novel fission yeast kinetochore protein required for centromeric silencing and chromosome segregation.The Journal of cell biology · 2003Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Precise segregation of chromosomes requires the activity of a specialized chromatin region, the centromere, that assembles the kinetochore complex to mediate the association with spindle microtubules. We show here that Mal2p, previously identified as a protein required for genome stability, is an essential component of the fission yeast centromere. Loss of functional Mal2p leads to extreme missegregation of chromosomes due to nondisjunction of sister chromatids and results in inviable cells. Mal2p associates specifically with the central region of the complex fission yeast centromere, where it is required for the specialized chromatin architecture as well as for transcriptional silencing of this region. Genetic evidence indicates that mal2(+) interacts with mis12(+), encoding another component of the inner centromere core complex. In addition, Mal2p is required for correct metaphase spindle length. Our data imply that the Mal2p protein is required to build up a functional fission yeast centromere.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.