ArticleMolecular and cellular biology2002
Cyclophilin A peptidyl-prolyl isomerase activity promotes ZPR1 nuclear export.
Article in Molecular and cellular biology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 66 citations in OpenAlex.
- Cyclophilin A: promising target in cancer therapy.Cancer biology & therapy · 2024Review
- Zinc-finger protein Zpr1 is a bespoke chaperone essential for eEF1A biogenesis.Molecular cell · 2023Article
- Ubiquitin Linkage Specificity of Deubiquitinases Determines Cyclophilin Nuclear Localization and Degradation.iScience · 2020Article
- Article
- Extracellular and Intracellular Cyclophilin A, Native and Post-Translationally Modified, Show Diverse and Specific Pathological Roles in Diseases.Arteriosclerosis, thrombosis, and vascular biology · 2018Review
- Cyclophilin A Aggravates Collagen-Induced Arthritis via Promoting Classically Activated Macrophages.Inflammation · 2017Article
- Microbial cyclophilins: specialized functions in virulence and beyond.World journal of microbiology & biotechnology · 2017Review
- Prolyl isomerases in gene transcription.Biochimica et biophysica acta · 2015Review
- Cyclophilin A: a key player for human disease.Cell death & disease · 2013Review
- Cyclophilins as modulators of viral replication.Viruses · 2013Review
- Saccharomyces cerevisiae KNU5377 stress response during high-temperature ethanol fermentation.Molecules and cells · 2013Article
- TRIM5 structure, HIV-1 capsid recognition, and innate immune signaling.Current opinion in virology · 2012Review
- HIV-1 capsid-cyclophilin interactions determine nuclear import pathway, integration targeting and replication efficiency.PLoS pathogens · 2011Article
- Differential gene expression in Arachis diogoi upon interaction with peanut late leaf spot pathogen, Phaeoisariopsis personata and characterization of a pathogen induced cyclophilin.Plant molecular biology · 2011Article
- Decarbonylated cyclophilin A Cpr1 protein protects Saccharomyces cerevisiae KNU5377Y when exposed to stress induced by menadione.Cell stress & chaperones · 2011Article
- Human cellular restriction factors that target HIV-1 replication.BMC medicine · 2009Review
- Transcriptomic analysis of the exit from dormancy of Aspergillus fumigatus conidia.BMC genomics · 2008Article
- Structural insights into the interaction of the evolutionarily conserved ZPR1 domain tandem with eukaryotic EF1A, receptors, and SMN complexes.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Changes in disulfide bond content of proteins in a yeast strain lacking major sources of NADPH.Free radical biology & medicine · 2007Article
- Identification and comparative analysis of sixteen fungal peptidyl-prolyl cis/trans isomerase repertoires.BMC genomics · 2006Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 2 countries.
Funding
Abstract
The peptidyl-prolyl isomerase (PPIase) cyclophilin A (Cpr1p) is conserved from eubacteria to mammals, yet its biological function has resisted elucidation. Unable to identify a phenotype that is suggestive of Cpr1p's function in a cpr1Delta Saccharomyces cerevisiae strain, we screened for CPR1-dependent strains. In all cases, dependence was conferred by mutations in ZPR1, a gene encoding an essential zinc finger protein. CPR1 dependence was suppressed by overexpression of EF1alpha (a translation factor that binds Zpr1p), Cpr6p (another cyclophilin), or Fpr1p (a structurally unrelated PPIase). Suppression by a panel of cyclophilin A mutants correlated with PPIase activity, confirming the relevance of this activity in CPR1-dependent strains. In CPR1(+) cells, wild-type Zpr1p was distributed equally between the nucleus and cytoplasm. In contrast, proteins encoded by CPR1-dependent alleles of ZPR1 accumulated in the nucleus, as did wild-type Zpr1p in cpr1Delta cells. Transport kinetic studies indicated that nuclear export of Zpr1p was defective in cpr1Delta cells, and rescue of this defect correlated with PPIase activity. Our results demonstrate a functional interaction between Cpr1p, Zpr1p, and EF1alpha, a role for Cpr1p in Zpr1p nuclear export, and a biological function for Cpr1p PPIase activity.
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Registered trials
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