ArticleGenetics2002
Genetic control of mammalian meiotic recombination. I. Variation in exchange frequencies among males from inbred mouse strains.
Article in Genetics, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
75 citing papers in PubMed, 113 citations in OpenAlex.
- Molecular assessment of recombination processing across genetically diverse mouse strains reveals sexually dimorphic determinants of crossover distribution beyond chromosome length.Molecular biology and evolution · 2026Article
- Chromosome length is not the sole determinant of sexually dimorphic crossover rates during mammalian meiosis: Insights from genetically diverse mouse strains.bioRxiv : the preprint server for biology · 2025Article
- Unraveling haplotype errors in the DFNA33 locus.Frontiers in genetics · 2023Article
- Article
- EWSR1 affects PRDM9-dependent histone 3 methylation and provides a link between recombination hotspots and the chromosome axis protein REC8.Molecular biology of the cell · 2021Article
- Higher Intercellular Variation in Genome-Wide Recombination Rate in Female Mice.Cytogenetic and genome research · 2021Article
- Crossover Interference: Shedding Light on the Evolution of Recombination.Annual review of genetics · 2019Review
- Article
- Genome-wide recombination map construction from single individuals using linked-read sequencing.Nature communications · 2019Article
- A rigorous measure of genome-wide genetic shuffling that takes into account crossover positions and Mendel's second law.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Interbreed variation in meiotic recombination rate and distribution in the domestic chickenArchives animal breeding · 2019Article
- The Mammalian Spermatogenesis Single-Cell Transcriptome, from Spermatogonial Stem Cells to Spermatids.Cell reports · 2018Article
- Imprinted gene dysregulation in aDevelopment (Cambridge, England) · 2018Article
- Effects of Demographic History on the Detection of Recombination Hotspots from Linkage Disequilibrium.Molecular biology and evolution · 2018Article
- Connecting theory and data to understand recombination rate evolution.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- Recombination correlates with synaptonemal complex length and chromatin loop size in bovids-insights into mammalian meiotic chromosomal organization.Chromosoma · 2017Article
- Population Genomics Reveals Speciation and Introgression between Brown Norway Rats and Their Sibling Species.Molecular biology and evolution · 2017Article
- Genetics of Genome-Wide Recombination Rate Evolution in Mice from an Isolated Island.Genetics · 2017Article
- Germline and reproductive tract effects intensify in male mice with successive generations of estrogenic exposure.PLoS genetics · 2017Article
- Embryonic exposure to the widely-used herbicide atrazine disrupts meiosis and normal follicle formation in female mice.Scientific reports · 2017Article
15 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Genetic background effects on the frequency of meiotic recombination have long been suspected in mice but never demonstrated in a systematic manner, especially in inbred strains. We used a recently described immunostaining technique to assess meiotic exchange patterns in male mice. We found that among four different inbred strains--CAST/Ei, A/J, C57BL/6, and SPRET/Ei--the mean number of meiotic exchanges per cell and, thus, the recombination rates in these genetic backgrounds were significantly different. These frequencies ranged from a low of 21.5 exchanges in CAST/Ei to a high of 24.9 in SPRET/Ei. We also found that, as expected, these crossover events were nonrandomly distributed and displayed positive interference. However, we found no evidence for significant differences in the patterns of crossover positioning between strains with different exchange frequencies. From our observations of >10,000 autosomal synaptonemal complexes, we conclude that achiasmate bivalents arise in the male mouse at a frequency of 0.1%. Thus, special mechanisms that segregate achiasmate chromosomes are unlikely to be an important component of mammalian male meiosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.