ArticleGenetics2002
Genetic requirements for spontaneous and transcription-stimulated mitotic recombination in Saccharomyces cerevisiae.
Article in Genetics, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 23 citations in OpenAlex.
- The Interplay between G-quadruplex and Transcription.Current medicinal chemistry · 2019Review
- The role of topoisomerase I in suppressing genome instability associated with a highly transcribed guanine-rich sequence is not restricted to preventing RNA:DNA hybrid accumulation.Nucleic acids research · 2016Article
- Shared genetic pathways contribute to the tolerance of endogenous and low-dose exogenous DNA damage in yeast.Genetics · 2014Article
- Targeted INO80 enhances subnuclear chromatin movement and ectopic homologous recombination.Genes & development · 2012Article
- Guanine repeat-containing sequences confer transcription-dependent instability in an orientation-specific manner in yeast.DNA repair · 2011Article
- Functional targeting of DNA damage to a nuclear pore-associated SUMO-dependent ubiquitin ligase.Science (New York, N.Y.) · 2008Article
- Role of the Saccharomyces cerevisiae Rad51 paralogs in sister chromatid recombination.Genetics · 2008Article
- Article
- Oligonucleotide transformation of yeast reveals mismatch repair complexes to be differentially active on DNA replication strands.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- DEG1, encoding the tRNA:pseudouridine synthase Pus3p, impacts HOT1-stimulated recombination in Saccharomyces cerevisiae.Molecular genetics and genomics : MGG · 2005Article
- Identification of a distinctive mutation spectrum associated with high levels of transcription in yeast.Molecular and cellular biology · 2004Article
- RAD51-dependent break-induced replication in yeast.Molecular and cellular biology · 2004Article
- Role of mismatch repair in the fidelity of RAD51- and RAD59-dependent recombination in Saccharomyces cerevisiae.Genetics · 2003Article
- Role of RAD52 epistasis group genes in homologous recombination and double-strand break repair.Microbiology and molecular biology reviews : MMBR · 2002Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 2 countries.
Funding
Abstract
The genetic requirements for spontaneous and transcription-stimulated mitotic recombination were determined using a recombination system that employs heterochromosomal lys2 substrates that can recombine only by crossover or only by gene conversion. The substrates were fused either to a constitutive low-level promoter (pLYS) or to a highly inducible promoter (pGAL). In the case of the "conversion-only" substrates the use of heterologous promoters allowed either the donor or the recipient allele to be highly transcribed. Transcription of the donor allele stimulated gene conversions in rad50, rad51, rad54, and rad59 mutants, but not in rad52, rad55, and rad57 mutants. In contrast, transcription of the recipient allele stimulated gene conversions in rad50, rad51, rad54, rad55, rad57, and rad59 mutants, but not in rad52 mutants. Finally, transcription stimulated crossovers in rad50, rad54, and rad59 mutants, but not in rad51, rad52, rad55, and rad57 mutants. These data are considered in relation to previously proposed molecular mechanisms of transcription-stimulated recombination and in relation to the roles of the recombination proteins.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.