ArticleLancet (London, England)2002
Cardiovascular status of infants and children of women infected with HIV-1 (P(2)C(2) HIV): a cohort study.
Article in Lancet (London, England), 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00005274 (Pediatric Pulmonary and Cardiovascular Complications of Vertically Transmitted HIV Infection), which is not on this map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Pediatric Pulmonary and Cardiovascular Complications of Vertically Transmitted HIV Infection (P2C2)
Who cites it
32 citing papers in PubMed, 85 citations in OpenAlex.
- Cardiac Effects of Antiretroviral-Naïve versus Antiretroviral-Exposed HIV Infection in Children.PloS one · 2016Trial
- Trial
- Birth defects among a cohort of infants born to HIV-infected women on antiretroviral medication.Journal of perinatal medicine · 2011Trial
- Direct and indirect cardiovascular and cardiometabolic sequelae of the combined anti-retroviral therapy on people living with HIV.Frontiers in physiology · 2023Review
- Impact of human immunodeficiency virus on pulmonary vascular disease.Global cardiology science & practice · 2021Review
- Metabolic Syndrome Prevalence and Cardiovascular Risk Assessment in HIV-Positive Men with and without Antiretroviral Therapy.Medicina (Kaunas, Lithuania) · 2021Article
- ECG abnormalities among HIV infected children placed on ART at Enugu, South East of Nigeria.African health sciences · 2020Article
- Review
- HIV-1-Associated Left Ventricular Cardiac Dysfunction in Humanized Mice.Scientific reports · 2020Article
- Rethinking COVID-19 in children: Lessons learned from pediatric viral and inflammatory cardiovascular diseases.Progress in pediatric cardiology · 2020Article
- Left ventricular diastolic dysfunction in HIV-uninfected infants exposed in utero to antiretroviral therapy.AIDS (London, England) · 2020Article
- Myocardial peak systolic velocity-a tool for cardiac screening of HIV-exposed uninfected children.European journal of pediatrics · 2020Observational
- A Comparison of Metabolic Outcomes Between Obese HIV-Exposed Uninfected Youth From the PHACS SMARTT Study and HIV-Unexposed Youth From the NHANES Study in the United States.Journal of acquired immune deficiency syndromes (1999) · 2019Article
- Cardiac and inflammatory biomarkers in perinatally HIV-infected and HIV-exposed uninfected children.AIDS (London, England) · 2018Article
- Cardiac Effects of Highly Active Antiretroviral Therapy in Perinatally HIV-Infected Children: The CHAART-2 Study.Journal of the American College of Cardiology · 2017Article
- Long-Term Effects of In Utero Antiretroviral Exposure: Systolic and Diastolic Function in HIV-Exposed Uninfected Youth.AIDS research and human retroviruses · 2016Article
- Maternal post-absorptive leucine kinetics during late pregnancy in US women with HIV taking antiretroviral therapy: a cross-sectional pilot study.Clinical nutrition ESPEN · 2015Article
- Human Immunodeficiency Virus and Heart Failure in Low- and Middle-Income Countries.JACC. Heart failure · 2015Review
- Heart failure in patients with human immunodeficiency virus infection: epidemiology, pathophysiology, treatment, and future research.Circulation · 2014Review
- Cardiac effects in perinatally HIV-infected and HIV-exposed but uninfected children and adolescents: a view from the United States of America.Journal of the International AIDS Society · 2013Review
Corrections and comments
- Commented on by
Authors and funding
12 authors at 8 institutions in 1 country.
Funding
Abstract
backgroundData from cross-sectional and short-term longitudinal studies have suggested that children infected with HIV-1 might have cardiovascular abnormalities. We aimed to investigate this hypothesis in a long-term cohort study.
methodsWe measured cardiovascular function every 4-6 months for up to 5 years in a birth cohort of 600 infants born to women infected with HIV-1. We included 93 infants infected with HIV-1 and 463 uninfected infants (internal controls) from the same cohort. We also included a cross-sectionally measured comparison group of 195 healthy children born to mothers who were not infected with HIV-1 (external controls).
findingsChildren infected with HIV-1 had a significantly higher heart rate at all ages (mean difference 10 bpm, 95% CI 8-13) than internal controls. At birth, both cohort groups of children had similar low left ventricular (LV) fractional shortening. At 8 months, fractional shortening was similar in internal and external controls, whereas in children infected with HIV-1, fractional shortening remained significantly lower than in controls for the first 20 months of life (mean difference from internal controls at 8 months 3.7%, 2.3-5.1). LV mass was similar at birth in both cohort groups, but became significantly higher in children with HIV-1 from 4-30 months (mean difference 2.4 g at 8 months, 0.9-3.9).
conclusionsVertically-transmitted HIV-1 infection is associated with persistent cardiovascular abnormalities identifiable shortly after birth. Irrespective of their HIV-1 status, infants born to women infected with HIV-1 have significantly worse cardiac function than other infants, suggesting that the uterine environment has an important role in postnatal cardiovascular abnormalities.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.