ArticleJournal of neuro-oncology2002
Molecular genetic changes in a series of neuroepithelial tumors of childhood.
Article in Journal of neuro-oncology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 27 citations in OpenAlex.
- Identification of NFE2L2 as a key biomarker associated with pyroptosis in gliomas through bioinformatics and experiments.Scientific reports · 2026Article
- Hsa_circ_0080229 upregulates the expression of murine double minute-2 (MDM2) and promotes glioma tumorigenesis and invasion via the miR-1827 sponging mechanism.Annals of translational medicine · 2021Article
- A microRNA profile of pediatric glioblastoma: The role of NUCKS1 upregulation.Molecular and clinical oncology · 2019Article
- A high expression of MTERF3 correlates with tumor progression and predicts poor outcomes in patients with brain glioma.International journal of clinical and experimental pathology · 2019Article
- Outcome of young children with high-grade glioma treated with irradiation-avoiding intensive chemotherapy regimens: Final report of the Head Start II and III trials.Pediatric blood & cancer · 2016Article
- Genome-wide copy number analysis in pediatric glioblastoma multiforme.American journal of cancer research · 2014Article
- Cytogenetic analysis of paediatric astrocytoma using comparative genomic hybridisation and fluorescence in-situ hybridisation.Journal of neuro-oncology · 2010Article
- Preclinical evaluation of radiation and perifosine in a genetically and histologically accurate model of brainstem glioma.Cancer research · 2010Article
- Pediatric glioblastomas: a histopathological and molecular genetic study.Neuro-oncology · 2009Article
- Protein expression of platelet-derived growth factor receptor correlates with malignant histology and PTEN with survival in childhood gliomas.Clinical cancer research : an official journal of the American Association for Cancer Research · 2008Article
- Molecular pathogenesis of pediatric astrocytic tumors.Neuro-oncology · 2007Article
- Biomarker discovery: a proteomic approach for brain cancer profiling.Cancer science · 2007Article
- Advances in treatment of pediatric brain tumors.NeuroRx : the journal of the American Society for Experimental NeuroTherapeutics · 2006Review
- Loss of p53 induces changes in the behavior of subventricular zone cells: implication for the genesis of glial tumors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Pediatric high-grade glioma: molecular genetic clues for innovative therapeutic approaches.Journal of neuro-oncology · 2005Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Amplification of the EGFR, mdm2, CDK4 and PDGFR A genes has been widely demonstrated in adult malignant gliomas, almost exclusively glioblastomas. To determine the role of these mutational events in pediatric astrocytic gliomas we investigated the presence of EGFR, mdm2, CDK4 and PDGFR A gene amplification in 38 childhood brain tumor biopsies, including 24 low-grade astrocytomas and 14 malignant tumors. We used differential PCR assay on DNA extracted either from paraffin embedded or frozen tissues. EGFR gene amplification was detected in 4 out of 14 malignant tumors; no low-grade astrocytoma showed amplification. Tumors with EGFR gene amplification were negative for the presence of p53 mutations, as observed in a previous study. One glioblastoma showed PDGFR A amplification, while no amplifications were observed for mdm2 and CDK4 genes. These data are in line with those obtained from studies on gliomas of adults and suggest the existence of two different subsets of malignant gliomas also in pediatric brain tumors: one carrying EGFR gene amplification, the other showing p53 mutations.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.