ArticleMolecular biology reports2002
The extent to which ATP demand controls the glycolytic flux depends strongly on the organism and conditions for growth.
Article in Molecular biology reports, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Investigating the role of FMicrobial cell factories · 2026Article
- The return of metabolism: biochemistry and physiology of glycolysis.Biological reviews of the Cambridge Philosophical Society · 2026Review
- Simultaneous saccharification and fermentation for D-lactic acid production using a metabolically engineered Escherichia coli adapted to high temperature.Biotechnology for biofuels and bioproducts · 2024Article
- Manganese Modulates Metabolic Activity and Redox Homeostasis in Translationally BlockedMicrobiology spectrum · 2022Article
- Principles and practice of designing microbial biocatalysts for fuel and chemical production.Journal of industrial microbiology & biotechnology · 2022Review
- Biosynthesis of adipic acid in metabolically engineered Saccharomyces cerevisiae.Journal of microbiology (Seoul, Korea) · 2020Article
- ATPase-based implementation of enforced ATP wasting in Saccharomyces cerevisiae for improved ethanol production.Biotechnology for biofuels · 2020Article
- A Novel Method for Long-Term Analysis of Lactic Acid and Ammonium Production in Non-growingFrontiers in bioengineering and biotechnology · 2020Article
- Control strategies in systemic metabolism.Nature metabolism · 2019Review
- Metabolic engineering ofBiotechnology for biofuels · 2019Article
- The Dynamics of Plasma Membrane, Metabolism and Respiration (PM-M-R) inFrontiers in microbiology · 2017Article
- Transcriptome and Multivariable Data Analysis of Corynebacterium glutamicum under Different Dissolved Oxygen Conditions in Bioreactors.PloS one · 2016Article
- Molecular and metabolic adaptations of Lactococcus lactis at near-zero growth rates.Applied and environmental microbiology · 2015Article
- Glycolysis is governed by growth regime and simple enzyme regulation in adherent MDCK cells.PLoS computational biology · 2014Article
- Response of Pseudomonas putida KT2440 to increased NADH and ATP demand.Applied and environmental microbiology · 2011Article
- Quantitative analysis of the high temperature-induced glycolytic flux increase in Saccharomyces cerevisiae reveals dominant metabolic regulation.The Journal of biological chemistry · 2008Article
- Isoflurane preserves energy balance in isolated hepatocytes during in vitro anoxia/reoxygenation.World journal of gastroenterology · 2005Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Using molecular genetics we have introduced uncoupled ATPase activity in two different bacterial species, Escherichia coli and Lactococcus lactis, and determined the elasticities of the growth rate and glycolytic flux towards the intracellular [ATP]/[ADP] ratio. During balanced growth in batch cultures of E. coli the ATP demand was found to have almost full control on the glycolytic flux (FCC=0.96) and the flux could be stimulated by 70%. In contrast to this, in L. lactis the control by ATP demand on the glycolytic flux was close to zero. However, when we used non-growing cells of L. lactis (which have a low glycolytic flux) the ATP demand had a high flux control and the flux could be stimulated more than two fold. We suggest that the extent to which ATP demand controls the glycolytic flux depends on how much excess capacity of glycolysis is present in the cells.
Indexed as
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Registered trials
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