ArticleProceedings of the National Academy of Sciences of the United States of America2002
Autologous transplantation of genetically modified iris pigment epithelial cells: a promising concept for the treatment of age-related macular degeneration and other disorders of the eye.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 77 citations in OpenAlex.
- Reduction of pathological retinal neovascularization, vessel obliteration, and artery tortuosity by PEDF protein in an oxygen-induced ischemic retinopathy rat model.FASEB bioAdvances · 2024Article
- Pigment Epithelium-Derived Factor as a Possible Treatment Agent for Choroidal Neovascularization.Oxidative medicine and cellular longevity · 2020Review
- Preclinical Evaluation of a Cell-Based Gene Therapy Using the Sleeping Beauty Transposon System in Choroidal Neovascularization.Molecular therapy. Methods & clinical development · 2019Article
- Retinal Vascular Degeneration in the Transgenic P23H Rat Model of Retinitis Pigmentosa.Frontiers in neuroanatomy · 2018Article
- Antiangiogenic and Neurogenic Activities of Sleeping Beauty-Mediated PEDF-Transfected RPE Cells In Vitro and In Vivo.BioMed research international · 2015Article
- Identification of PLXDC1 and PLXDC2 as the transmembrane receptors for the multifunctional factor PEDF.eLife · 2014Article
- Current treatment limitations in age-related macular degeneration and future approaches based on cell therapy and tissue engineering.Journal of ophthalmology · 2014Review
- Role of toll-like receptors in human iris pigment epithelial cells and their response to pathogen-associated molecular patterns.Journal of inflammation (London, England) · 2014Article
- Neural Stem Cells Derived by Small Molecules Preserve Vision.Translational vision science & technology · 2013Article
- High efficiency non-viral transfection of retinal and iris pigment epithelial cells with pigment epithelium-derived factor.Gene therapy · 2010Article
- Gutless adenovirus: last-generation adenovirus for gene therapy.Gene therapy · 2005Review
- [Transplantation of iris pigment epithelium].Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft · 2004Article
- Inhibition of glioma invasion by overexpression of pigment epithelium-derived factor.Cancer gene therapy · 2004Article
- Tissue engineering and cell based therapies, from the bench to the clinic: the potential to replace, repair and regenerate.Reproductive biology and endocrinology : RB&E · 2003Review
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Authors and funding
8 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Age-related macular degeneration (ARMD) is the leading cause for visual impairment and blindness in the elder population. Laser photocoagulation, photodynamic therapy and excision of neovascular membranes have met with limited success. Submacular transplantation of autologous iris pigment epithelial (IPE) cells has been proposed to replace the damaged retinal pigment epithelium following surgical removal of the membranes. We tested our hypothesis that the subretinal transplantation of genetically modified autologous IPE cells expressing biological therapeutics might be a promising strategy for the treatment of ARMD and other retinal disorders. Pigment epithelium-derived factor (PEDF) has strong antiangiogenic and neuroprotective activities in the eye. Subretinal transplantation of PEDF expressing IPE cells inhibited pathological choroidal neovascularization in rat models of laser-induced rupture of Bruch's membrane and of oxygen induced ischemic retinopathy. PEDF expressing IPE transplants also increased the survival and preserved rhodopsin expression of photoreceptor cells in the RCS rat, a model of retinal degeneration. These findings suggest a promising concept for the treatment of ARMD and other retinal disorders.
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