Evidence map›Paper›PMID 12239336›Full record

ArticleJournal of virology2002

Identification and expression of immunogenic proteins of a disease-associated marine turtle herpesvirus.

Sadie S Coberley, Richard C Condit, Lawrence H Herbst, Paul A Klein

Open access · greenAbstract read
In one paragraph

Article in Journal of virology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Viruses in reptiles.Veterinary research · 2011
    Review
  8. The order Herpesvirales.Archives of virology · 2009
    Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Sadie S CoberleyInterdisciplinary Program in Biomedical Science, College of Medicine, University of Florida, Gainesville, FL 32610, USA.
Richard C Condit
Lawrence H Herbst
Paul A Klein
Albert Einstein College of Medicine · USUniversity of Florida · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Herpesviruses are associated with several diseases of marine turtles, including lung-eye-trachea disease (LETD) and fibropapillomatosis. Two approaches were used to identify immunodominant antigens of LETV, the LETD-associated herpesvirus. The first approach targeted glycoprotein B, which is known to be immunogenic and neutralizing in other species. The second strategy identified LETV proteins recognized on Western blots by antibodies in immune green turtle plasma. A 38-kDa protein was resolved by two-dimensional gel electrophoresis, sequenced, and identified as a scaffolding protein encoded by the overlapping open reading frames of UL26 and UL26.5. Glycoprotein B and the scaffolding protein were cloned and expressed in Escherichia coli. The expressed proteins were recognized on Western blots by antibodies in immune green turtle plasma. Phylogenetic studies based on UL26, DNA polymerase, and glycoprotein B revealed that LETV clusters with the alphaherpesviruses.

Indexed as

AlphaherpesvirinaeAnimalsBase SequenceCapsidDNA, ViralHerpesviridaeHerpesviridae InfectionsHumansMolecular Sequence DataSerine EndopeptidasesTurtlesViral Envelope ProteinsViral ProteinsDNA cleavage and packaging proteins, HerpesvirusDNA, Viralglycoprotein B, SimplexvirusICP35 protein, Human herpesvirus 1scaffold protein, Herpes simplex virus-1Serine EndopeptidasesViral Envelope ProteinsViral Proteins

Identifiers

PMID12239336
PMCPMC136575
OpenAlexW2101667064

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.