ArticleThe Plant cell1997
A Transcriptionally Active State Is Required for Post-Transcriptional Silencing (Cosuppression) of Nitrate Reductase Host Genes and Transgenes.
Article in The Plant cell, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 91 citations in OpenAlex.
- Metabolic engineering for tobacco quality improvement: Advances and perspectives.Metabolic engineering communications · 2026Review
- Strain, procedures, and tools for reproducible genetic transformation and genome editing of the emerging plant model Spirodela polyrhiza.The New phytologist · 2026Article
- Transcriptional Regulation of SWEET15_A01 by MYB44/bHLH3 Modulates Carbon Allocation in Cotton Ovule and Fibre to Affect Seed and Fibre Traits.Plant biotechnology journal · 2026Article
- The plant siRNA landscape.The Plant cell · 2024Review
- Quantitative Investigation ofInternational journal of molecular sciences · 2023Article
- A Brief History of the Discovery of RNA-Mediated Antiviral Immune Defenses in Vector Mosquitos.Microbiology and molecular biology reviews : MMBR · 2023Review
- RNA silencing in the life cycle of soybean: multiple restriction systems and spatiotemporal variation associated with plant architecture.Transgenic research · 2017Article
- Reconsidering plant memory: Intersections between stress recovery, RNA turnover, and epigenetics.Science advances · 2016Review
- Epigenetic silencing in transgenic plants.Frontiers in plant science · 2015Review
- Early-flowering sweet orange mutant 'x11' as a model for functional genomic studies of Citrus.BMC research notes · 2014Article
- Recognizing the enemy within: licensing RNA-guided genome defense.Trends in biochemical sciences · 2014Review
- RNA silencing is resistant to low-temperature in grapevine.PloS one · 2013Article
- Coincident sequence-specific RNA degradation of linked transgenes in the plant genome.Plant molecular biology · 2012Article
- Light intensity affects RNA silencing of a transgene in Nicotiana benthamiana plants.BMC plant biology · 2010Article
- Distinct extremely abundant siRNAs associated with cosuppression in petunia.RNA (New York, N.Y.) · 2009Article
- ARGONAUTE 1 homeostasis invokes the coordinate action of the microRNA and siRNA pathways.EMBO reports · 2009Article
- Suppression of the barley uroporphyrinogen III synthase gene by a Ds activation tagging element generates developmental photosensitivity.The Plant cell · 2009Article
- Rice UDP-glucose pyrophosphorylase1 is essential for pollen callose deposition and its cosuppression results in a new type of thermosensitive genic male sterility.The Plant cell · 2007Article
- The trans-silencing capacity of invertedly repeated transgenes depends on their epigenetic state in tobacco.Nucleic acids research · 2006Article
- Effects of length and location on the cellular response to double-stranded RNA.Microbiology and molecular biology reviews : MMBR · 2004Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Using tobacco nitrate reductase cosuppression as a model system of post-transcriptional gene silencing, we analyzed the influence of DNA and RNA dosages both together and independently. For this purpose, zero, one, two, or four active or transcriptionally silenced copies of a cauliflower mosaic virus 35S-Nia2 transgene were combined by transformation and subsequent crosses with zero, one, two, three, or four active, disrupted, or transcriptionally repressed copies of the wild-type host Nia genes. The analysis of the corresponding transgenic lines revealed that (1) the percentage of isogenic plants that are affected by cosuppression depends directly upon the relative dosage of both host gene and transgene; (2) transcriptional silencing of the 35S-Nia transgene impedes cosuppression; and (3) the absence of host gene transcription reduces the frequency of cosuppression or delays its triggering. Taken together, these results indicate that transgene DNA per se is not sufficient to trigger post-transcriptional cosuppression of nitrate reductase host genes and transgenes. The requirement for a transcriptionally active state is discussed with respect to both the RNA dosage and the DNA-DNA pairing hypotheses.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.