ArticleMolecular and cellular biochemistry2002
Post-translational modifications of cardiac tubulin during chronic heart failure in the rat.
Article in Molecular and cellular biochemistry, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 42 citations in OpenAlex.
- Spastin-mediated severing of glutamylated microtubules controls cardiomyocyte coupling.Nature cardiovascular research · 2026Article
- The role of the dystrophin glycoprotein complex in muscle cell mechanotransduction.Communications biology · 2022Review
- Tubulin expression and modification in heart failure with preserved ejection fraction (HFpEF).Scientific reports · 2022Article
- Knockout of Sorbin And SH3 Domain Containing 2 (Sorbs2) in Cardiomyocytes Leads to Dilated Cardiomyopathy in Mice.Journal of the American Heart Association · 2022Article
- Structural basis of tubulin detyrosination by the vasohibin-SVBP enzyme complex.Nature structural & molecular biology · 2019Article
- Mitochondrial dynamics and respiration within cells with increased open pore cytoskeletal meshes.Biology open · 2017Article
- A comprehensive review of the bioenergetics of fatty acid and glucose metabolism in the healthy and failing heart in nondiabetic condition.Heart failure reviews · 2017Review
- The Effects of Guizhi Gancao Decoction on Pressure Overload-Induced Heart Failure and Posttranslational Modifications of Tubulin in Mice.Evidence-based complementary and alternative medicine : eCAM · 2017Article
- Detyrosinated microtubules buckle and bear load in contracting cardiomyocytes.Science (New York, N.Y.) · 2016Article
- Detyrosinated microtubules modulate mechanotransduction in heart and skeletal muscle.Nature communications · 2015Article
- The role of tubulin in the mitochondrial metabolism and arrangement in muscle cells.Journal of bioenergetics and biomembranes · 2014Review
- Article
- Mechanical modulation of cardiac microtubules.Pflugers Archiv : European journal of physiology · 2011Review
- Opposing actions of extracellular signal-regulated kinase (ERK) and signal transducer and activator of transcription 3 (STAT3) in regulating microtubule stabilization during cardiac hypertrophy.The Journal of biological chemistry · 2011Article
- The p38/MAPK pathway regulates microtubule polymerization through phosphorylation of MAP4 and Op18 in hypoxic cells.Cellular and molecular life sciences : CMLS · 2010Article
- Proliferating cardiac microtubules.American journal of physiology. Heart and circulatory physiology · 2009Article
- Local energetic regulation of sarcoplasmic and myosin ATPase is differently impaired in rats with heart failure.The Journal of physiology · 2008Article
- Heart failure: a model of cardiac and skeletal muscle energetic failure.Pflugers Archiv : European journal of physiology · 2006Review
- Functional properties of the titin/connectin-associated proteins, the muscle-specific RING finger proteins (MURFs), in striated muscle.Journal of muscle research and cell motility · 2005Article
- Microtubule composition: cryptography of dynamic polymers.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cytoskeletal reorganization has been shown to participate in cellular remodeling and in the alterations of mechanical function of isolated cardiomyocytes during pressure overload hypertrophy. Post-translational modifications of tubulin towards stabilization of microtubules have also been described in animal models of compensatory hypertrophy, but the status of the microtubules network in end stage heart failure is not clearly established. Using a rat model of congestive heart failure (CHF) induced by aortic banding, we studied the expression of alpha- and beta-tubulin, as well as their post-translational modification and distribution in the soluble and polymerized fraction by immunoblotting. We found an accumulation of alpha- and beta-tubulin protein content specifically in the soluble fraction with no change in the polymerized fraction. Amongst the several variants of alpha-tubulin examined, only detyrosinated Glu-tubulin and deglutamylated delta2-tubulin levels were selectively increased during heart failure. Glu-tubulin accumulated in the polymerized fraction while delta2-tubulin levels were increased in the soluble fraction in CHF hearts. These results show that a profound remodeling of the microtubule network occurs in heart failure. This remodeling suggests an increase in the stability of the microtubule network which is discussed in terms of possible functional consequences.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.