ArticleThe Journal of experimental medicine2002
Vaccination with minigenes encoding V(H)-derived major histocompatibility complex class I-binding epitopes activates cytotoxic T cells that ablate autoantibody-producing B cells and inhibit lupus.
Article in The Journal of experimental medicine, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 57 citations in OpenAlex.
- Pathogenesis and novel therapeutics of regulatory T cell subsets and interleukin-2 therapy in systemic lupus erythematosus.Frontiers in immunology · 2023Review
- CD8Rheumatology and immunology research · 2021Review
- B cell depletion in murine lupus using cytotoxic T lymphocytes in vivo: Feasibility and benefit.Cellular immunology · 2020Article
- In vivo maturation of allo-specific CD8 CTL and prevention of lupus-like graft-versus-host disease is critically dependent on T cell signaling through the TNF p75 receptor but not the TNF p55 receptor.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Germline deletion of β2 microglobulin or CD1d reduces anti-phospholipid antibody, but increases autoantibodies against non-phospholipid antigens in the NZB/W F1 model of lupus.Arthritis research & therapy · 2013Article
- Genes, tolerance and systemic autoimmunity.Autoimmunity reviews · 2012Review
- Article
- Brief treatment with iNKT cell ligand α-galactosylceramide confers a long-term protection against lupus.Journal of clinical immunology · 2012Article
- Invariant NKT cells inhibit autoreactive B cells in a contact- and CD1d-dependent manner.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Article
- Pathogenic and Epiphenomenal Anti-DNA Antibodies in SLE.Autoimmune diseases · 2010Article
- Therapeutic potential of CD8+ cytotoxic T lymphocytes in SLE.Autoimmunity reviews · 2009Review
- Fas expression on antigen-specific T cells has costimulatory, helper, and down-regulatory functions in vivo for cytotoxic T cell responses but not for T cell-dependent B cell responses.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- CTL-promoting effects of CD40 stimulation outweigh B cell-stimulatory effects resulting in B cell elimination and disease improvement in a murine model of lupus.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- A role for sex chromosome complement in the female bias in autoimmune disease.The Journal of experimental medicine · 2008Article
- Dual roles of immunoregulatory cytokine TGF-beta in the pathogenesis of autoimmunity-mediated organ damage.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- Examining the role of CD1d and natural killer T cells in the development of nephritis in a genetically susceptible lupus model.Arthritis and rheumatism · 2007Article
- A female preponderance for chemically induced lupus in SJL/J mice.Clinical immunology (Orlando, Fla.) · 2007Article
- SLE: translating lessons from model systems to human disease.Trends in immunology · 2005Review
- Cellular and molecular mechanisms of regulation of autoantibody production in lupus.Annals of the New York Academy of Sciences · 2005Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Current treatments for autoantibody-mediated diseases, such as lupus, can cause nonspecific immune suppression. In this paper, we used a bioinformatic approach to identify major histocompatibility complex class I-binding epitopes in the heavy chain variable region of anti-DNA antibodies from lupus-prone (NZB/NZW F1) mice. Vaccination of such mice with plasmid DNA vectors encoding these epitopes induced CD8(+) T cells that killed anti-DNA antibody-producing B cells, reduced serum anti-DNA antibody levels, retarded the development of nephritis, and improved survival. Vaccine-mediated induction of anti-V(H) cytotoxic T lymphocytes that ablate autoreactive B cells represents a novel approach to treat autoantibody-mediated diseases.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.