ArticleThe EMBO journal2002
Fission yeast Mor2/Cps12, a protein similar to Drosophila Furry, is essential for cell morphogenesis and its mutation induces Wee1-dependent G(2) delay.
Article in The EMBO journal, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 65 citations in OpenAlex.
- De novo variants in FRYL are associated with developmental delay, intellectual disability, and dysmorphic features.American journal of human genetics · 2024Article
- The fission yeast NDR kinase Orb6 and its signalling pathway MOR regulate cytoplasmic microtubule organization during the cell cycle.Open biology · 2024Article
- Furry is required for cell movements during gastrulation and functionally interacts with NDR1.Scientific reports · 2021Article
- Furry protein suppresses nuclear localization of yes-associated protein (YAP) by activating NDR kinase and binding to YAP.The Journal of biological chemistry · 2020Article
- Mob Family Proteins: Regulatory Partners in Hippo and Hippo-Like Intracellular Signaling Pathways.Frontiers in cell and developmental biology · 2020Review
- Article
- Fryl deficiency is associated with defective kidney development and function in mice.Experimental biology and medicine (Maywood, N.J.) · 2018Article
- Cell Polarity in Yeast.Annual review of cell and developmental biology · 2017Review
- MST kinases in development and disease.The Journal of cell biology · 2015Review
- Insight into actin organization and function in cytokinesis from analysis of fission yeast mutants.Genetics · 2013Article
- Identification of SIN pathway targets reveals mechanisms of crosstalk between NDR kinase pathways.Current biology : CB · 2013Article
- The NDR kinase scaffold HYM1/MO25 is essential for MAK2 map kinase signaling in Neurospora crassa.PLoS genetics · 2012Article
- The RAM network in pathogenic fungi.Eukaryotic cell · 2012Review
- Spindle pole body components are reorganized during fission yeast meiosis.Molecular biology of the cell · 2012Article
- Cbk1 kinase and Bck2 control MAP kinase activation and inactivation during heat shock.Molecular biology of the cell · 2011Article
- Crosstalk between NDR kinase pathways coordinates cell cycle dependent actin rearrangements.Cell division · 2011Article
- Xenopus furry contributes to release of microRNA gene silencing.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- The mitosis-to-interphase transition is coordinated by cross talk between the SIN and MOR pathways in Schizosaccharomyces pombe.The Journal of cell biology · 2010Article
- The Drosophila Fry protein interacts with Trc and is highly mobile in vivo.BMC developmental biology · 2010Article
- Shaping fission yeast with microtubules.Cold Spring Harbor perspectives in biology · 2009Review
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fission yeast cells identify growing regions at the opposite ends of the cell, producing the rod-like shape. The positioning of the growth zone(s) and the polarized growth require CLIP170-like protein Tip1 and the Ndr kinase Orb6, respectively. Here, we show that the mor2/cps12 mutation disrupts the localization of F-actin at the cell ends, producing spherical cells and concomitantly inducing a G(2) delay at 36 degrees C. Mor2 is important for the localization of F-actin at the cell end(s) but not at the medial region, and is essential for the restriction of the growth zone(s) where Tip1 targets. Mor2 is homologous to the Drosophila Furry protein, which is required to maintain the integrity of cellular extensions, and is localized at both cell ends and the medial region of the cell in an actin-dependent fashion. Cellular localization of Mor2 and Orb6 was interdependent. The tyrosine kinase Wee1 is necessary for the G(2) delay and maintenance of viability of the mor2 mutant. These results indicate that Mor2 plays an essential role in cell morphogenesis in concert with Orb6, and the mutation activates the mechanism coordinating morphogenesis with cell cycle progression.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.