ArticleThe EMBO journal2002
Nonself recognition is mediated by HET-C heterocomplex formation during vegetative incompatibility.
Article in The EMBO journal, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Molecular Mechanisms Regulating Cell Fusion and Heterokaryon Formation in Filamentous Fungi.Microbiology spectrum · 2017Review
- Nonself recognition through intermolecular disulfide bond formation of ribonucleotide reductase in neurospora.Genetics · 2013Article
- Trans-species activity of a nonself recognition domain.BMC microbiology · 2013Article
- Diversification of a protein kinase cascade: IME-2 is involved in nonself recognition and programmed cell death in Neurospora crassa.Genetics · 2012Article
- Polymorphic toxin systems: Comprehensive characterization of trafficking modes, processing, mechanisms of action, immunity and ecology using comparative genomics.Biology direct · 2012Article
- Limited vegetative compatibility as a cause of somatic recombination in Trichoderma pseudokoningii.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2011Article
- Article
- De novo assembly of a 40 Mb eukaryotic genome from short sequence reads: Sordaria macrospora, a model organism for fungal morphogenesis.PLoS genetics · 2010Article
- Transcriptional profiling and functional analysis of heterokaryon incompatibility in Neurospora crassa reveals that reactive oxygen species, but not metacaspases, are associated with programmed cell death.Microbiology (Reading, England) · 2009Article
- Sexual and vegetative compatibility genes in the aspergilli.Studies in mycology · 2007Article
- VIB-1 is required for expression of genes necessary for programmed cell death in Neurospora crassa.Eukaryotic cell · 2006Article
- LPS-induced TNF-alpha factor (LITAF)-deficient mice express reduced LPS-induced cytokine: Evidence for LITAF-dependent LPS signaling pathways.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Article
- Comparative analysis of programmed cell death pathways in filamentous fungi.BMC genomics · 2005Article
- Potential link between the NIMA mitotic kinase and nuclear membrane fission during mitotic exit in Aspergillus nidulans.Eukaryotic cell · 2004Article
- Fatal attraction: nonself recognition and heterokaryon incompatibility in filamentous fungi.Eukaryotic cell · 2003Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Nonself recognition during vegetative growth in filamentous fungi is mediated by heterokaryon incompatibility (het) loci. In Neurospora crassa, het-c is one of 11 het loci. Three allelic specificity groups, termed het-c(OR), het-c(PA) and het-c(GR), exist in natural populations. Heterokaryons or partial diploids that contain het-c alleles of alternative specificity show severe growth inhibition, repression of conidiation and hyphal compartmentation and death (HCD). Using epitope-tagged HET-C, we show that nonself recognition is mediated by the presence of a heterocomplex composed of polypeptides encoded by het-c alleles of alternative specificity. The HET-C heterocomplex localized to the plasma membrane (PM); PM-bound HET-C heterocomplexes occurred in all three het-c incompatible allelic interactions. Strains containing het-c constructs deleted for a predicted signal peptide sequence formed HET-C heterocomplexes in the cytoplasm and showed a growth arrest phenotype. Our finding is a step towards understanding nonself recognition mechanisms that operate during vegetative growth in filamentous fungi, and provides a model for investigating relationships between recognition mechanisms and cell death.
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