ArticleThe EMBO journal2002
Crystal structure of the BEACH domain reveals an unusual fold and extensive association with a novel PH domain.
Article in The EMBO journal, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 101 citations in OpenAlex.
- BEACH domain proteins function as cargo-sorting adaptors in secretory and endocytic pathways.The Journal of cell biology · 2024Article
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- Mutations in RABE1C suppress the spirrig mutant phenotype.PloS one · 2024Article
- The lysosomal trafficking regulator "LYST": an 80-year traffic jam.Frontiers in immunology · 2024Review
- Recent progress in type 1 classical dendritic cell cross-presentation - cytosolic, vacuolar, or both?Current opinion in immunology · 2023Review
- The evolving biology of cross-presentation.Seminars in immunology · 2023Review
- Dendritic cells in cancer immunology.Cellular & molecular immunology · 2022Review
- Article
- Functional analysis of the BEige and Chediak-Higashi domain gene MpFrontiers in plant science · 2022Article
- Genetic Analyses of Amphotericin B Susceptibility inJournal of fungi (Basel, Switzerland) · 2021Article
- Novel manifestations of immune dysregulation and granule defects in gray platelet syndrome.Blood · 2020Article
- Evolutionary Comparison of the Developmental/Physiological Phenotype and the Molecular Behavior of SPIRRIG BetweenFrontiers in plant science · 2020Article
- A Spectrum of Clinical Findings from ALPS to CVID: Several Novel LRBA Defects.Journal of clinical immunology · 2019Article
- LRBA in the endomembrane system.Colombia medica (Cali, Colombia) · 2018Review
- Potential for therapeutic targeting of AKAP signaling complexes in nervous system disorders.Pharmacology & therapeutics · 2018Review
- Nbeal2 interacts with Dock7, Sec16a, and Vac14.Blood · 2018Article
- Molecular Dissection of Neurobeachin Function at Excitatory Synapses.Frontiers in synaptic neuroscience · 2018Article
- The BEACH protein LRBA is required for hair bundle maintenance in cochlear hair cells and for hearing.EMBO reports · 2017Article
- Whole Genome Sequencing Identifies Novel Compound Heterozygous Lysosomal Trafficking Regulator Gene Mutations Associated with Autosomal Recessive Chediak-Higashi Syndrome.Scientific reports · 2017Article
- ALFY-Controlled DVL3 Autophagy Regulates Wnt Signaling, Determining Human Brain Size.PLoS genetics · 2016Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
The BEACH domain is highly conserved in a large family of eukaryotic proteins, and is crucial for their functions in vesicle trafficking, membrane dynamics and receptor signaling. However, it does not share any sequence homology with other proteins. Here we report the crystal structure at 2.9 A resolution of the BEACH domain of human neurobeachin. It shows that the BEACH domain has a new and unusual polypeptide backbone fold, as the peptide segments in its core do not assume regular secondary structures. Unexpectedly, the structure also reveals that the BEACH domain is in extensive association with a novel, weakly conserved pleckstrin-homology (PH) domain. Consistent with the structural analysis, biochemical studies show that the PH and BEACH domains have strong interactions, suggesting they may function as a single unit. Functional studies in intact cells demonstrate the requirement of both the PH and the BEACH domains for activity. A prominent groove at the interface between the two domains may be used to recruit their binding partners.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.