ArticleAntimicrobial agents and chemotherapy2002
In vitro synergistic interaction between amphotericin B and pentamidine against Scedosporium prolificans.
Article in Antimicrobial agents and chemotherapy, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 38 citations in OpenAlex.
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- Techniques for the Assessment of In Vitro and In Vivo Antifungal Combinations.Journal of fungi (Basel, Switzerland) · 2021Review
- Treatment options in emerging mold infections.Current infectious disease reports · 2008Article
- Infections caused by Scedosporium spp.Clinical microbiology reviews · 2008Review
- Efficacy of ambruticin analogs in a murine model of invasive pulmonary aspergillosis.Antimicrobial agents and chemotherapy · 2006Article
- Caspofungin and liposomal amphotericin B therapy of experimental murine scedosporiosis.Antimicrobial agents and chemotherapy · 2005Article
- Combination treatment of invasive fungal infections.Clinical microbiology reviews · 2005Review
- Pentamidine is active in vitro against Fusarium species.Antimicrobial agents and chemotherapy · 2003Article
- Scedosporium prolificans osteomyelitis in an immunocompetent child treated with voriconazole and caspofungin, as well as locally applied polyhexamethylene biguanide.Journal of clinical microbiology · 2003Review
- Antifungal activity of nonantifungal drugs.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2003Review
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To develop new approaches for the treatment of invasive infections caused by Scedosporium prolificans, the in vitro interaction between amphotericin B and pentamidine against 30 clinical isolates was evaluated using a checkerboard microdilution method based on the National Committee for Clinical Laboratory Standards M38-P guidelines. The interaction between the drugs was analyzed using fractional inhibitory concentration index (FICI) analysis and response surface modeling. Amphotericin B alone was inactive against all the isolates. The geometric mean MIC for pentamidine was 57 micro g/ml (range, 8 to 256 micro g/ml; MIC at which 50% of the isolates tested were inhibited [MIC(50)], 64 micro g/ml; MIC(90), 128 micro g/ml). The combination was synergistic against 28 of 30 isolates (93.3%) by FICI analysis and 30 of 30 (100%) by response surface modeling analysis. Antagonism was not observed.
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