ArticleAmerican journal of physiology. Heart and circulatory physiology2002
An implantable bolus infusion pump for use in freely moving, nontethered rats.
Article in American journal of physiology. Heart and circulatory physiology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 37 citations in OpenAlex.
- Ceftriaxone inhibits stress-induced bladder hyperalgesia and alters cerebral micturition and nociceptive circuits in the rat: A multidisciplinary approach to the study of urologic chronic pelvic pain syndrome research network study.Neurourology and urodynamics · 2020Article
- Exercise modulates neuronal activation in the micturition circuit of chronically stressed rats: A multidisciplinary approach to the study of urologic chronic pelvic pain syndrome (MAPP) research network study.Physiology & behavior · 2020Article
- Cerebral perfusion mapping during retrieval of spatial memory in rats.Behavioural brain research · 2019Article
- Recruitment of prefrontal-striatal circuit in response to skilled motor challenge.Neuroreport · 2017Article
- Article
- Recruitment of the prefrontal cortex and cerebellum in Parkinsonian rats following skilled aerobic exercise.Neurobiology of disease · 2015Article
- A [14C]iodoantipyrine study of inter-regional correlations of neural substrates following central post-stroke pain in rats.Molecular pain · 2015Article
- Exercise training reinstates cortico-cortical sensorimotor functional connectivity following striatal lesioning: development and application of a subregional-level analytic toolbox for perfusion autoradiographs of the rat brain.Frontiers in physics · 2014Article
- Remote brain network changes after unilateral cortical impact injury and their modulation by acetylcholinesterase inhibition.Journal of neurotrauma · 2013Article
- Functional reorganization of motor and limbic circuits after exercise training in a rat model of bilateral parkinsonism.PloS one · 2013Article
- Alterations in prefrontal-limbic functional activation and connectivity in chronic stress-induced visceral hyperalgesia.PloS one · 2013Article
- MEMS-enabled implantable drug infusion pumps for laboratory animal research, preclinical, and clinical applications.Advanced drug delivery reviews · 2012Review
- Antenatal maternal stress alters functional brain responses in adult offspring during conditioned fear.Brain research · 2011Article
- Powering an implantable minipump with a multi-layered printed circuit coil for drug infusion applications in rodents.Annals of biomedical engineering · 2010Article
- A low power, on demand electrothermal valve for wireless drug delivery applications.Lab on a chip · 2010Article
- A Parylene MEMS Electrothermal Valve.Journal of microelectromechanical systems : a joint IEEE and ASME publication on microstructures, microactuators, microsensors, and microsystems · 2009Article
- Changes in regional brain perfusion during functional brain activation: comparison of [(64)Cu]-PTSM with [(14)C]-Iodoantipyrine.Brain research · 2008Article
- Article
- Brain maps on the go: functional imaging during motor challenge in animals.Methods (San Diego, Calif.) · 2008Review
- Reorganization of functional brain maps after exercise training: Importance of cerebellar-thalamic-cortical pathway.Brain research · 2007Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
One of the current constraints on functional neuroimaging in animals is that to avoid movement artifacts during data acquisition, subjects need to be immobilized, sedated, or anesthetized. Such measures limit the behaviors that can be examined, and introduce the additional variables of stress or anesthetic agents that may confound meaningful interpretation. This study provides a description of the design and characteristics of a self-contained, implantable microbolus infusion pump (MIP) that allows triggering of a bolus injection at a distance in conscious, behaving rats that are not restrained or tethered. The MIP is externally triggered by a pulse of infrared light and allows in vivo bolus drug delivery. We describe application of this technology to the intravenous bolus delivery of iodo[(14)C]antipyrine in a freely moving animal, followed immediately by lethal injection, rapid removal of the brain, and analysis of regional cerebral blood flow tissue radioactivity with the use of autoradiography. The ability to investigate changes in brain activation in nonrestrained animals makes the MIP a powerful tool for evaluation of complex behaviors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.