ArticleKinetoplastid biology and disease2002
From the cell biology to the development of new chemotherapeutic approaches against trypanosomatids: dreams and reality.
Article in Kinetoplastid biology and disease, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 82 citations in OpenAlex.
- Cell Death and Unprecedent Cytoskeletal Changes inChemical & biomedical imaging · 2026Article
- Trypanocidal and Anti-Inflammatory Effects of ThreePharmaceutics · 2024Article
- Antileishmanial Drug Discovery and Development: Time to Reset the Model?Microorganisms · 2021Review
- Cruzipain Sulfotopes-Specific Antibodies Generate Cardiac Tissue Abnormalities and FavorFrontiers in cellular and infection microbiology · 2021Article
- Galectins in Chagas Disease: A Missing Link BetweenFrontiers in microbiology · 2021Review
- Cell death pathways in pathogenic trypanosomatids: lessons of (over)kill.Cell death & disease · 2019Review
- Complement system contributes to modulate the infectivity of susceptible TcI strains of Trypanosoma cruzi.Memorias do Instituto Oswaldo Cruz · 2018Article
- The Kinetoplast of Trypanosomatids: From Early Studies of Electron Microscopy to Recent Advances in Atomic Force Microscopy.Scanning · 2018Review
- Effects of a novel β-lapachone derivative on Trypanosoma cruzi: Parasite death involving apoptosis, autophagy and necrosis.International journal for parasitology. Drugs and drug resistance · 2016Article
- Differential Gel Electrophoresis (DIGE) Evaluation of Naphthoimidazoles Mode of Action: A Study in Trypanosoma cruzi Bloodstream Trypomastigotes.PLoS neglected tropical diseases · 2016Article
- Crystal structure of a heterodimer of editosome interaction proteins in complex with two copies of a cross-reacting nanobody.Nucleic acids research · 2012Article
- Structures of a key interaction protein from the Trypanosoma brucei editosome in complex with single domain antibodies.Journal of structural biology · 2011Article
- Protease expression by microorganisms and its relevance to crucial physiological/pathological events.World journal of biological chemistry · 2011Article
- Ecto-phosphatases in protozoan parasites: possible roles in nutrition, growth and ROS sensing.Journal of bioenergetics and biomembranes · 2011Review
- Expression and subcellular localization of kinetoplast-associated proteins in the different developmental stages of Trypanosoma cruzi.BMC microbiology · 2009Article
- Subcellular proteomics of Trypanosoma cruzi reservosomes.Proteomics · 2009Article
- Functional genomic characterization of mRNAs associated with TcPUF6, a pumilio-like protein from Trypanosoma cruzi.The Journal of biological chemistry · 2008Article
- Cellular effects of reversed amidines on Trypanosoma cruzi.Antimicrobial agents and chemotherapy · 2007Article
- Small-subunit rRNA processome proteins are translationally regulated during differentiation of Trypanosoma cruzi.Eukaryotic cell · 2007Article
- Uptake of host cell transforming growth factor-beta by Trypanosoma cruzi amastigotes in cardiomyocytes: potential role in parasite cycle completion.The American journal of pathology · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Members of the Trypanosomatidae family comprise a large number of species that are causative agents of important diseases such as sleeping sickness, Chagas' disease and Leishmaniasis. These organisms are also of biological interest since they are able to change the morphology according to the environment where they live, through a process of reversible cell transformation, and possess structures and organelles that are not found in mammalian cells. This review analyses the process of transformation, which takes place during the life cycle of Trypanosoma cruzi in the vertebrate and invertebrate hosts. Special attention is given to the interaction of the parasite with vertebrate cells. In addition, the present knowledge of structures and organelles such as the nucleus, the plasma membrane, the sub-pellicular microtubules, the flagellum, the kinetoplast-mitochondrion complex, the peroxisome (glycosome), the acidocalcisome and the structures and organelles involved in the endocytic pathway, is reviewed from a cell biology perspective. The possible use of available data for the development of new anti parasite drugs is also discussed.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.