ArticleMolecular psychiatry2002
Dopamine D4 receptor and tyrosine hydroxylase genes in bipolar disorder: evidence for a role of DRD4.
Article in Molecular psychiatry, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 62 citations in OpenAlex.
- Keeping Track of the Genealogy of Heterozygotes Using Epigenetic Reference Codes and Breeding Tables.Frontiers in behavioral neuroscience · 2021Article
- The influence of five monoamine genes on trajectories of depressive symptoms across adolescence and young adulthood.Development and psychopathology · 2012Article
- The effect of reduced dopamine D4 receptor expression in the 5-choice continuous performance task: Separating response inhibition from premature responding.Behavioural brain research · 2011Article
- Imprinting in the schizophrenia candidate gene GABRB2 encoding GABA(A) receptor β(2) subunit.Molecular psychiatry · 2011Article
- MEG auditory evoked fields suggest altered structural/functional asymmetry in primary but not secondary auditory cortex in bipolar disorder.Bipolar disorders · 2009Article
- The genetics of bipolar disorder: genome 'hot regions,' genes, new potential candidates and future directions.Molecular psychiatry · 2008Review
- Epigenetics in mood disorders.Environmental health and preventive medicine · 2008Article
- Genetics of bipolar disorder.Dialogues in clinical neuroscience · 2008Review
- A linkage and family-based association analysis of a potential neurocognitive endophenotype of bipolar disorder.Neuromolecular medicine · 2007Article
- The psychopathology and treatment of bipolar disorder.Annual review of clinical psychology · 2006Review
- Bipolar I disorder and schizophrenia: a 440-single-nucleotide polymorphism screen of 64 candidate genes among Ashkenazi Jewish case-parent trios.American journal of human genetics · 2005Article
- Genetic tests of biologic systems in affective disorders.Molecular psychiatry · 2005Review
- Genetic features of antidepressant induced mania and hypo-mania in bipolar disorder.Psychopharmacology · 2004Article
- Sex- and lineage-specific inheritance of depression-like behavior in the rat.Mammalian genome : official journal of the International Mammalian Genome Society · 2004Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The involvement of the mesocorticolimbic dopamine system in behaviors that are compromised in patients with mood disorder has led to the investigation of dopamine system genes as candidates for bipolar disorder. In particular, the functional VNTRs in the exon III of the dopamine D4 (DRD4) and in intron I of the tyrosine hydroxylase (TH) genes have been investigated in numerous association studies that have produced contrasting results. Likewise, linkage studies in multiplex bipolar families have shown both positive and negative results for markers in close proximity to DRD4 and TH on 11p15.5. We performed a linkage disequilibrium analysis of the DRD4 and TH VNTRs in a sample of 145 nuclear families comprised of DSM-IV bipolar probands and their biological parents. An excess of transmissions and non transmissions was observed for the DRD4 4- and 2-repeat alleles respectively. The biased transmission showed a parent of origin effect (POE) since it was derived almost exclusively from the maternal meiosis (4-repeat allele maternally transmitted 40 times vs 20 times non-transmitted; chi(2) = 6.667; df = 1; P = 0.009; while paternally transmitted 26 times vs 21 times non-transmitted; chi(2) = 0.531; df = 1; P = 0.46). The analysis of TH did not reveal biased transmission of intron I VNTR alleles. Although replication of our study is necessary, the fact that DRD4 exhibit POE and is located on 11p15.5, in close proximity to a cluster of imprinted genes, suggests that genomic imprinting may be operating in bipolar disorder.
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