ArticleThe Journal of physiology2002
Contribution of a calcium-activated non-specific conductance to NMDA receptor-mediated synaptic potentials in granule cells of the frog olfactory bulb.
Article in The Journal of physiology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 44 citations in OpenAlex.
- Modulation of Neural Microcircuits That Control Complex Dynamics in Olfactory Networks.Frontiers in cellular neuroscience · 2021Article
- Local Postsynaptic Signaling on Slow Time Scales in Reciprocal Olfactory Bulb Granule Cell Spines Matches Asynchronous Release.Frontiers in synaptic neuroscience · 2020Article
- 9-Phenanthrol modulates postinhibitory rebound and afterhyperpolarizing potentials in an excitatory motor neuron of the medicinal leech.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2017Article
- Rapid Feedforward Inhibition and Asynchronous Excitation Regulate Granule Cell Activity in the Mammalian Main Olfactory Bulb.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- α(1A)-Adrenergic regulation of inhibition in the olfactory bulb.The Journal of physiology · 2013Article
- A two-layer biophysical model of cholinergic neuromodulation in olfactory bulb.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- NMDA receptor-dependent synaptic activation of TRPC channels in olfactory bulb granule cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Synaptic activity unmasks dopamine D2 receptor modulation of a specific class of layer V pyramidal neurons in prefrontal cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Morphological analysis of activity-reduced adult-born neurons in the mouse olfactory bulb.Frontiers in neuroscience · 2011Article
- Synaptic mechanism for the sustained activation of oculomotor integrator circuits in the rat prepositus hypoglossi nucleus: contribution of Ca2+-permeable AMPA receptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Calcium buffering in rodent olfactory bulb granule cells and mitral cells.The Journal of physiology · 2009Article
- Excitatory actions of noradrenaline and metabotropic glutamate receptor activation in granule cells of the accessory olfactory bulb.Journal of neurophysiology · 2009Article
- L-type Ca2+ current in frog tectal recurrent neurons determines the NMDA receptor activation on efferent neuron.Experimental brain research · 2009Article
- Transient activity induces a long-lasting increase in the excitability of olfactory bulb interneurons.Journal of neurophysiology · 2008Article
- Muscarinic receptor activation modulates granule cell excitability and potentiates inhibition onto mitral cells in the rat olfactory bulb.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Topological reorganization of odor representations in the olfactory bulb.PLoS biology · 2007Article
- Glomerulus-specific, long-latency activity in the olfactory bulb granule cell network.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Ca2+-dependent regulation of a non-selective cation channel from Aplysia bag cell neurones.The Journal of physiology · 2006Article
- An in vitro study of long-term potentiation in the carp (Cyprinus carpio L.) olfactory bulb.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2006Article
- Branch-specific Ca2+ influx from Na+-dependent dendritic spikes in olfactory granule cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We studied granule cells (GCs) in the intact frog olfactory bulb (OB) by combining whole-cell recordings and functional two-photon Ca(2+) imaging in an in vitro nose-brain preparation. GCs are local interneurones that shape OB output via distributed dendrodendritic inhibition of OB projection neurones, the mitral-tufted cells (MTCs). In contrast to MTCs, GCs exhibited a Ca(2+)-activated non-specific cation conductance (I(CAN)) that could be evoked through strong synaptic stimulation or suprathreshold current injection. Photolysis of the caged Ca(2+) chelator o-nitrophenol-EGTA resulted in activation of an inward current with a reversal potential within the range -20 to +10 mV. I(CAN) in GCs was suppressed by the intracellular Ca(2+) chelator BAPTA (0.5-5.0 mM), but not by EGTA (up to 5 mM). The current persisted in whole-cell recordings for up to 1.5 h post-breakthrough, was observed during perforated-patch recordings and was independent of ionotropic glutamate and GABA(A) receptor activity. In current-clamp mode, GC responses to synaptic stimulation consisted of an initial AMPA-mediated conductance followed by a late-phase APV-sensitive plateau (100-500 ms). BAPTA-mediated suppression of I(CAN) resulted in a selective reduction of the late component of the evoked synaptic potential, consistent with a positive feedback relationship between NMDA receptor (NMDAR) current and I(CAN). I(CAN) requires Ca(2+) influx either through voltage-gated Ca(2+) channels or possibly NMDARs, both of which have a high threshold for activation in GCs, predicting a functional role for this current in the selective enhancement of strong synaptic inputs to GCs.
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