ArticlePlant physiology1995
Changes in Protein Isoprenylation during the Growth of Suspension-Cultured Tobacco Cells.
Article in Plant physiology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 50 citations in OpenAlex.
- Methyl-Jasmonate Functions as a Molecular Switch Promoting Cross-Talk between Pathways for the Biosynthesis of Isoprenoid Backbones Used to Modify Proteins in Plants.Plants (Basel, Switzerland) · 2024Article
- S-carvone suppresses cellulase-induced capsidiol production in Nicotiana tabacum by interfering with protein isoprenylation.Plant physiology · 2014Article
- Proteins prenylated by type I protein geranylgeranyltransferase act positively on the jasmonate signalling pathway triggering the biosynthesis of monoterpene indole alkaloids in Catharanthus roseus.Plant cell reports · 2009Article
- Complete blockage of the mevalonate pathway results in male gametophyte lethality.Journal of experimental botany · 2009Article
- Farnesylation directs AtIPT3 subcellular localization and modulates cytokinin biosynthesis in Arabidopsis.Plant physiology · 2008Article
- Developmentally controlled farnesylation modulates AtNAP1;1 function in cell proliferation and cell expansion during Arabidopsis leaf development.Plant physiology · 2006Article
- Roquefortine/oxaline biosynthesis pathway metabolites in Penicillium ser. Corymbifera: in planta production and implications for competitive fitness.Journal of chemical ecology · 2005Article
- Review
- Farnesol-induced cell death and stimulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity in tobacco cv bright yellow-2 cells.Plant physiology · 2000Article
- Prenylation of the floral transcription factor APETALA1 modulates its function.The Plant cell · 2000Article
- Functional requirement of plant farnesyltransferase during development in Arabidopsis.The Plant cell · 2000Article
- Cloning of the Arabidopsis WIGGUM gene identifies a role for farnesylation in meristem development.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Protein prenylation in plants: old friends and new targets.Plant molecular biology · 1999Review
- Prenylcysteine alpha-carboxyl methyltransferase in suspension-cultured tobacco cellsPlant physiology · 1998Article
- Biochemical characterization of stromal and thylakoid-bound isoforms of isoprene synthase in willow leavesPlant physiology · 1998Article
- A Vacuole-Associated Annexin Protein, VCaB42, Correlates with the Expansion of Tobacco Cells.Plant physiology · 1997Article
- Plant farnesyltransferase can restore yeast Ras signaling and mating.Molecular and cellular biology · 1997Article
- In Vitro Prenylation of the Small GTPase Rac13 of Cotton.Plant physiology · 1996Article
- Protein farnesyltransferase in plants: molecular characterization and involvement in cell cycle control.The Plant cell · 1996Article
- Identification of cDNAs encoding isoprenylated proteins.Molecular biotechnology · 1996Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Isoprenylation facilitates the association of proteins with intracellular membranes and/or other proteins. In mammalian and yeast cells, isoprenylated proteins are involved in signal transduction, cell division, organization of the cytoskeleton, and vesicular transport. Recently, protein isoprenylation has been demonstrated in higher plants, but little is currently known about the functions of isoprenylated plant proteins. We report that inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase (lovastatin) or prenyl:protein transferases (perilly alcohol) severely impair the growth of cultured tobacco (Nicotiana tabacum) cells but only when added within the first 2 d following transfer to fresh medium, before any increase in culture volume is detectable. This "window" of sensitivity to inhibitors of protein isoprenylation correlates temporally with an increase in [14C]mevalonate incorporation into tobacco cell proteins in vitro. We have also observed a marked increase in farnesyl:protein transferase activity at this early time in the growth of tobacco cultures. In contrast, type I geranylgeranyl:protein transferase activity does not change significantly during culture growth. Although these events coincide with the replication of DNA, I [mu]M lovastatin-treated cells are capable of DNA synthesis, suggesting that lovastatin-induced cell growth arrest is not due to inhibition of DNA replication. Together, these data support the hypothesis that protein isoprenylation is necessary for the early stages of growth of tobacco cultures.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.