ArticleInfection and immunity2002
Effect of omp10 or omp19 deletion on Brucella abortus outer membrane properties and virulence in mice.
Article in Infection and immunity, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 49 citations in OpenAlex.
- Brucella abortus outer membrane protein modulates host immunity via B-cell receptor-associated protein.AMB Express · 2026Article
- Pathogenicity and virulence ofVirulence · 2025Review
- Identifying immunoreactive proteins in brucellin for enhanced brucellosis diagnosis: a proteomic approach.Frontiers in microbiology · 2025Article
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- AJournal of microbiology and biotechnology · 2022Article
- Evaluation of the Combined Use of Major Outer Membrane Proteins in the Serodiagnosis of Brucellosis.Infection and drug resistance · 2022Article
- An ArsR Transcriptional Regulator FacilitatesInternational journal of molecular sciences · 2021Article
- Screening of potential vaccine candidates against pathogenic Brucella spp. using compositive reverse vaccinology.Veterinary research · 2021Article
- Uncovering the Hidden Credentials ofMicrobiology and molecular biology reviews : MMBR · 2021Review
- Article
- RNA-Seq Analysis Reveals the Role of Omp16 inFrontiers in veterinary science · 2021Article
- Pan-Proteomic Analysis and Elucidation of Protein Abundance among the Closely RelatedBiomolecules · 2020Article
- Comparison of Immune Effects BetweenFrontiers in veterinary science · 2020Article
- Protection of BALB/c mice against pathogenicIranian journal of basic medical sciences · 2019Article
- Omp19 EnablesFrontiers in immunology · 2019Article
- Identification of Cross-Protective Potential Antigens against PathogenicJournal of immunology research · 2018Article
- WadD, a NewFrontiers in microbiology · 2018Article
- Characterization of Cell Envelope Multiple Mutants ofFrontiers in microbiology · 2018Article
- Mutant Brucella abortus membrane fusogenic protein induces protection against challenge infection in mice.Infection and immunity · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The distinctive properties of Brucella outer membrane have been considered to be critical for Brucella sp. virulence. Among the outer membrane molecules possibly related to these properties, Omp10 and Omp19 are immunoreactive outer membrane lipoproteins. Moreover, these proteins of Brucella could constitute a new family of outer membrane proteins specifically encountered in the family RHIZOBIACEAE: We evaluated the impact of omp10 or omp19 deletion on Brucella abortus outer membrane properties and virulence in mice. The omp10 mutant was dramatically attenuated for survival in mice and was defective for growth in minimal medium but was not impaired in intracellular growth in vitro, nor does it display clear modification of the outer membrane properties. Significantly fewer brucellae were recovered from the spleens of mice infected with the omp19 mutant than from those of mice infected with the parent strain at 4 and 8 weeks postinfection. The omp19 mutant exhibited an increase in sensitivity to the polycation polymyxin B and to sodium deoxycholate. These results indicate that inactivation of the omp19 gene alters the outer membrane properties of B. abortus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.