ArticleAnnals of the rheumatic diseases2002
Interleukin 17 synergises with tumour necrosis factor alpha to induce cartilage destruction in vitro.
Article in Annals of the rheumatic diseases, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 105 citations in OpenAlex.
- Programmed cell death-related gene S100A9 promotes macrophage M1 polarization and chondrocyte apoptosis in rheumatoid arthritis.Biology direct · 2026Article
- Mendelian randomization and transcriptome analysis identified immune-related biomarkers for osteoarthritis.Frontiers in immunology · 2024Article
- Molecular Basic of Pharmacotherapy of Cytokine Imbalance as a Component of Intervertebral Disc Degeneration Treatment.International journal of molecular sciences · 2023Review
- Alantolactone alleviates collagen-induced arthritis and inhibits Th17 cell differentiation through modulation of STAT3 signalling.Pharmaceutical biology · 2021Article
- [The role of helper T cell in the pathogenesis of osteoarthritis].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2020Review
- Dextromethorphan Exhibits Anti-inflammatory and Immunomodulatory Effects in a Murine Model of Collagen-Induced Arthritis and in Human Rheumatoid Arthritis.Scientific reports · 2017Article
- Interleukin-25 Produced by Synoviocytes Has Anti-inflammatory Effects by Acting As a Receptor Antagonist for Interleukin-17A Function.Frontiers in immunology · 2017Article
- Secukinumab for rheumatology: development and its potential place in therapy.Drug design, development and therapy · 2016Review
- Lapatinib ameliorates experimental arthritis in rats.Inflammation · 2015Article
- Tyrosine kinase inhibitor tyrphostin AG490 retards chronic joint inflammation in mice.Inflammation · 2014Article
- Patients with the most advanced rheumatoid arthritis remain with Th1 systemic defects after TNF inhibitors treatment despite clinical improvement.Rheumatology international · 2014Article
- Interleukin-17A: a unique pathway in immune-mediated diseases: psoriasis, psoriatic arthritis and rheumatoid arthritis.Immunology · 2014Review
- A potential role of myeloid DAP12-associating lectin (MDL)-1 in the regulation of inflammation in rheumatoid arthritis patients.PloS one · 2014Article
- Serum levels of IL-17, IL-4, and INFγ in Serbian patients with early rheumatoid arthritis.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2014Article
- Small molecule inhibitors of WNT/β-catenin signaling block IL-1β- and TNFα-induced cartilage degradation.Arthritis research & therapy · 2013Article
- Pathologic finding of increased expression of interleukin-17 in the synovial tissue of rheumatoid arthritis patients.International journal of clinical and experimental pathology · 2013Article
- Levels of circulating Th17 cells and regulatory T cells in ankylosing spondylitis patients with an inadequate response to anti-TNF-α therapy.Journal of clinical immunology · 2013Article
- Influence of infliximab on cytokines network and markers of bone remodeling in rheumatoid arthritis patients.Yonsei medical journal · 2013Article
- Induction of Th17 lymphocytes and Treg cells by monocyte-derived dendritic cells in patients with rheumatoid arthritis and systemic lupus erythematosus.Clinical & developmental immunology · 2013Article
- Effects of TNF inhibitor on innate inflammatory and Th17 cytokines in stimulated whole blood from rheumatoid arthritis patients.Inflammopharmacology · 2012Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInterleukin 17 (IL17) is produced by activated T cells and has been implicated in the development of bone lesions and cartilage degradation in rheumatoid arthritis (RA).
objectiveTo determine whether IL17, alone or together with tumour necrosis factor alpha (TNFalpha), induces cartilage destruction in vitro.
methodsFetal mouse metatarsals stripped of endogenous osteoclast precursors were used to study the effect of IL17 on cartilage degradation independently of osteoclastic resorption. Cartilage destruction was analysed histologically by Alcian blue staining.
resultsIL17 alone, up to 100 ng/ml, had no effect on the cartilage of fetal mouse metatarsals. IL17 (>/=0.1 ng/ml), however, induced severe cartilage degradation when given together with TNFalpha (>/=1 ng/ml). The cytokine combination decreased Alcian blue staining, a marker of proteoglycans, throughout the metatarsals and induced loss of the proliferating and early hypertrophic chondrocyte zones. TNFalpha alone also decreased Alcian blue staining, but not as dramatically as the cytokine combination. In addition, it did not induce loss of chondrocyte zones. Treatment with inhibitors of matrix metalloproteinase (MMP) activity and nitric oxide synthesis showed that MMP activity played a part in cartilage degradation, whereas nitric oxide production did not.
conclusionsIL17, together with TNFalpha, induced cartilage degradation in fetal mouse metatarsals in vitro. IL17 may, therefore, participate in the development of cartilage destruction associated with RA by enhancing the effects of TNFalpha and may provide a potential therapeutic target.
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