Evidence map›Paper›PMID 12228152›Full record

ReviewAnnals of the rheumatic diseases2002

Treating human autoimmune disease by depleting B cells.

R J Looney

Registry-linked trialAbstract readCommentReview
In one paragraph

Review in Annals of the rheumatic diseases, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00261118 (Phase 3), which is not on this map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00261118 phase2 / phase3completednot on this mapstarted 2004, after this paper: background citation

Phase 3: Randomised Controlled Trial of Rituximab in Active Ulcerative Colitis

TypeinterventionalSponsorRoyal Liverpool University HospitalRan2004 to 2009Enrolled24ConditionsUlcerative ColitisArmsRituximab
3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Targeting B cells in treatment of autoimmunity.Current opinion in immunology · 2016
    Review
  6. Article
  7. Therapeutic apheresis in autoimmune diseases.Open access rheumatology : research and reviews · 2013
    Review
  8. The role of B cells in systemic sclerosis.Biologics : targets & therapy · 2008
    Article
  9. Rituximab as a therapeutic tool in severe mixed cryoglobulinemia.Clinical reviews in allergy & immunology · 2008
    Review
  10. Article
  11. Article
  12. SLE - Rituximab in lupus.Arthritis research & therapy · 2003
    Article
  13. B cells as a therapeutic target in autoimmune disease.Arthritis research & therapy · 2003
    Article
  14. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author.

R J LooneyUniversity of Rochester, Rochester, New York 14642, USA. John_looney@URMC.Rochester.edu

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Antibodies, MonoclonalAntibodies, Monoclonal, Murine-DerivedAutoimmune DiseasesB-LymphocytesHumansImmunologic MemoryImmunosuppressive AgentsLymphocyte DepletionRituximabAntibodies, MonoclonalAntibodies, Monoclonal, Murine-DerivedImmunosuppressive AgentsRituximab

Identifiers

PMID12228152
PMCPMC1753906

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.