ArticleCurrent infectious disease reports2002
The Role of CD4(+) and CD8(+) T Cells in Controlling HIV Infection.
Article in Current infectious disease reports, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 33 citations in OpenAlex.
- A Single Dose Study of Pembrolizumab in People With HIV Infection Who are Immunologic Nonresponders.Open forum infectious diseases · 2026Trial
- Artificial Intelligence and Machine Learning Based Prediction of Viral Load and CD4 Status of People Living with HIV (PLWH) on Anti-Retroviral Treatment in Gedeo Zone Public Hospitals.International journal of general medicine · 2023Article
- The CD8Microbiology and molecular biology reviews : MMBR · 2021Review
- Article
- Review
- Head-to-Head Comparison of Poxvirus NYVAC and ALVAC Vectors Expressing Identical HIV-1 Clade C Immunogens in Prime-Boost Combination with Env Protein in Nonhuman Primates.Journal of virology · 2015Article
- Use of RT-defective HIV virions: new tool to evaluate specific response in chronic asymptomatic HIV-infected individuals.PloS one · 2013Article
- Amplifying and quantifying HIV-1 RNA in HIV infected individuals with viral loads below the limit of detection by standard clinical assays.Journal of visualized experiments : JoVE · 2011Article
- Article
- Decimated or missing in action: CD4+ T cells as targets and effectors in the pathogenesis of primary HIV infection.Current HIV/AIDS reports · 2006Review
- Infectious molecular clones from a simian immunodeficiency virus-infected rapid-progressor (RP) macaque: evidence of differential selection of RP-specific envelope mutations in vitro and in vivo.Journal of virology · 2006Article
- Advances in understanding immunologic control of HIV infection.Current HIV/AIDS reports · 2004Review
- Immune failure in the absence of profound CD4+ T-lymphocyte depletion in simian immunodeficiency virus-infected rapid progressor macaques.Journal of virology · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Presently, it is thought that virus-specific T cells play a major role in restricting lentiviral replication and determining the rate of disease progression in humans. However, it remains unclear why this restriction fails in the majority of infected individuals. The major exception is a rare subgroup of HIV-infected long-term nonprogressors (LTNPs) who have been infected for approximately 20 years yet maintain normal CD4(+) T-cell counts and less than 50 copies of viral RNA/mL of plasma. Although virus-specific cellular (CD4(+) and CD8(+) T lymphocytes) immune responses have been shown to exert some degree of in vivo control of HIV replication, the precise correlates of protective immunity differentiating LTNPs from patients with progressive disease remain unknown. A greater understanding of the components and magnitude of an effective immune response to HIV is an important step toward the development of effective vaccines and immunotherapies.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.