ArticleOncogene2002
Inactivation of Apc perturbs mammary development, but only directly results in acanthoma in the context of Tcf-1 deficiency.
Article in Oncogene, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 42 citations in OpenAlex.
- Perturbed myoepithelial cell differentiation in BRCA mutation carriers and in ductal carcinoma in situ.Nature communications · 2019Article
- Functional redundancy between Apc and Apc2 regulates tissue homeostasis and prevents tumorigenesis in murine mammary epithelium.Oncogene · 2017Article
- Effect of glycogen synthase kinase-3 inactivation on mouse mammary gland development and oncogenesis.Oncogene · 2015Article
- Integrated morphodynamic signalling of the mammary gland.Nature reviews. Molecular cell biology · 2011Review
- Apc mutation enhances PyMT-induced mammary tumorigenesis.PloS one · 2011Article
- Primary cilia regulate branching morphogenesis during mammary gland development.Current biology : CB · 2010Article
- Key signaling nodes in mammary gland development and cancer: β-catenin.Breast cancer research : BCR · 2010Review
- A targeted constitutive mutation in the APC tumor suppressor gene underlies mammary but not intestinal tumorigenesis.PLoS genetics · 2009Article
- Genetic mechanisms in Apc-mediated mammary tumorigenesis.PLoS genetics · 2009Article
- Article
- Apc deficiency predisposes to renal carcinoma in the mouse.Oncogene · 2005Article
- Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration.Genes & development · 2004Article
- Wnt proteins in mammary development and cancer.Journal of mammary gland biology and neoplasia · 2004Review
- Article
- Wnt-cadherin connections in normal and neoplastic mammary epithelium.Journal of mammary gland biology and neoplasia · 2003Review
- Helix-loop-helix proteins in mammary gland development and breast cancer.Journal of mammary gland biology and neoplasia · 2003Review
- Beta-catenin and Tcfs in mammary development and cancer.Journal of mammary gland biology and neoplasia · 2003Review
- Beta-catenin: a transforming actor on many stages.Breast cancer research : BCR · 2003Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 3 countries.
Funding
Abstract
Apc (adenomatous polyposis coli) encodes a tumour suppressor gene that is mutated in the majority of colorectal cancers. Recent evidence has also implicated Apc mutations in the aetiology of breast tumours. Apc is a component of the canonical Wnt signal transduction pathway, of which one target is Tcf-1. In the mouse, mutations of both Apc and Tcf-1 have been implicated in mammary tumorigenesis. We have conditionally inactivated Apc in both the presence and absence of Tcf-1 to examine the function of these genes in both normal and neoplastic development. Mice harbouring mammary-specific mutations in Apc show markedly delayed development of the mammary ductal network. During lactation, the mice develop multiple metaplastic growths which, surprisingly, do not spontaneously progress to neoplasia up to a year following their induction. However, additional deficiency of Tcf-1 completely blocks normal mammary development and results in acanthoma.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.