ArticleJournal of computational neuroscience
Modulatory effects of parallel fiber and molecular layer interneuron synaptic activity on purkinje cell responses to ascending segment input: a modeling study.
Article in Journal of computational neuroscience. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 37 citations in OpenAlex.
- Random innervation of cerebellar Purkinje cells as a substrate for diverse representational learning.bioRxiv : the preprint server for biology · 2026Article
- Inferring phenomenological models of first passage processes.PLoS computational biology · 2021Article
- Diverse Neuron Properties and Complex Network Dynamics in the Cerebellar Cortical Inhibitory Circuit.Frontiers in molecular neuroscience · 2019Article
- Modeling the Cerebellar Microcircuit: New Strategies for a Long-Standing Issue.Frontiers in cellular neuroscience · 2016Review
- The 40-year history of modeling active dendrites in cerebellar Purkinje cells: emergence of the first single cell "community model".Frontiers in computational neuroscience · 2015Review
- Reevaluation of the beam and radial hypotheses of parallel fiber action in the cerebellar cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Quantitative organization of GABAergic synapses in the molecular layer of the mouse cerebellar cortex.PloS one · 2010Article
- Dendritic excitability modulates dendritic information processing in a purkinje cell model.Frontiers in computational neuroscience · 2010Article
- The functional equivalence of ascending and parallel fiber inputs in cerebellar computation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Distinct subtypes of basolateral amygdala taste neurons reflect palatability and reward.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Behavioral states, network states, and sensory response variability.Journal of neurophysiology · 2008Review
- Stars and stripes in the cerebellar cortex: a voltage sensitive dye study.Frontiers in systems neuroscience · 2007Article
- Differential susceptibility to synaptic plasticity reveals a functional specialization of ascending axon and parallel fiber synapses to cerebellar Purkinje cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Differences in transmission properties and susceptibility to long-term depression reveal functional specialization of ascending axon and parallel fiber synapses to Purkinje cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Synaptic shunting by a baseline of synaptic conductances modulates responses to inhibitory input volleys in cerebellar Purkinje cells.Cerebellum (London, England) · 2004Article
- No parallel fiber volleys in the cerebellar cortex: evidence from cross-correlation analysis between Purkinje cells in a computer model and in recordings from anesthetized rats.Journal of computational neuroscienceArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Based on anatomical, physiological, and model-based studies, it has been proposed that synapses associated with the ascending segment of granule cell axons provide the principle excitatory drive on Purkinje cells which is then modulated by the more numerous parallel fiber synapses. In this study we have evaluated this idea using a detailed compartmental model of a cerebellar Purkinje cell by providing identical ascending segment synaptic inputs during different levels of random parallel fiber and molecular interneuron input. Results suggest that background inputs from parallel fibers and molecular layer interneurons can have a substantial effect on the response of Purkinje cells to ascending segment inputs. Interestingly, these effects are not reflected in the average firing rate of the Purkinje cell and are thus entirely dendritic in effect. These results are considered in the context of the known segregated spatial distribution of the parallel fibers and ascending segment synapses and a new hypothesis concerning the functional organization of cerebellar cortical circuitry.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.