ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2002
Limbic thalamic lesions, appetitively motivated discrimination learning, and training-induced neuronal activity in rabbits.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 38 citations in OpenAlex.
- Retrosplenial cortex codes for permanent landmarks.PloS one · 2012Trial
- Retrosplenial cortex and aversive conditioning.Frontiers in behavioral neuroscience · 2024Review
- Human thalamic low-frequency oscillations correlate with expected value and outcomes during reinforcement learning.Nature communications · 2023Article
- Time to retire the serial Papez circuit: Implications for space, memory, and attention.Neuroscience and biobehavioral reviews · 2022Review
- The limbic memory circuit and the neural basis of contextual memory.Neurobiology of learning and memory · 2022Article
- The anterior thalamic nuclei and cognition: A role beyond space?Neuroscience and biobehavioral reviews · 2021Review
- The retrosplenial cortical role in encoding behaviorally significant cues.Behavioral neuroscience · 2018Review
- Anterior thalamic nuclei, but not retrosplenial cortex, lesions abolish latent inhibition in rats.Behavioral neuroscience · 2018Article
- When is the rat retrosplenial cortex required for stimulus integration?Behavioral neuroscience · 2018Article
- Retrosplenial cortex and its role in spatial cognition.Brain and neuroscience advances · 2018Review
- Retrosplenial Cortical Neurons Encode Navigational Cues, Trajectories and Reward Locations During Goal Directed Navigation.Cerebral cortex (New York, N.Y. : 1991) · 2017Article
- A novel role for the rat retrosplenial cortex in cognitive control.Learning & memory (Cold Spring Harbor, N.Y.) · 2014Article
- Cues, context, and long-term memory: the role of the retrosplenial cortex in spatial cognition.Frontiers in human neuroscience · 2014Review
- The origin of projections from the posterior cingulate and retrosplenial cortices to the anterior, medial dorsal and laterodorsal thalamic nuclei of macaque monkeys.The European journal of neuroscience · 2014Article
- The role of the anterior, mediodorsal, and parafascicular thalamus in instrumental conditioning.Frontiers in systems neuroscience · 2013Review
- Nucleus accumbens, thalamus and insula connectivity during incentive anticipation in typical adults and adolescents.NeuroImage · 2013Article
- Complimentary roles of the hippocampus and retrosplenial cortex in behavioral context discrimination.Hippocampus · 2012Article
- Default-mode-like network activation in awake rodents.PloS one · 2011Article
- Roles of the anterior cingulate cortex and medial thalamus in short-term and long-term aversive information processing.Molecular pain · 2010Article
- Brain fMRI reactivity to smoking-related images before and during extended smoking abstinence.Experimental and clinical psychopharmacology · 2009Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
A substantial literature implicates the anterior and mediodorsal (limbic) thalamic nuclei and the reciprocally interconnected areas of cingulate cortex in learning, memory, and attentional processes. Previous studies have shown that limbic thalamic lesions severely impair discriminative avoidance learning and that they block development of training-induced neuronal activity in the cingulate cortex. The present study investigated the possibility that the limbic thalamus and cingulate cortex are involved in reward-based discriminative approach learning, wherein head-extension responses yielding oral contact with a drinking spout that was inserted into the conditioning chamber after a positive conditional stimulus (CS+) were reinforced with a water reward but responses to the spout after a negative conditional stimulus (CS-) were not reinforced. In this task, the rabbits learned primarily to omit their prepotent responses to the spout on CS- trials. Acquisition was severely impaired in rabbits given limbic thalamic lesions before training. As during avoidance learning, posterior cingulate cortical neurons of control rabbits developed learning-related neuronal responses to task-relevant stimuli, but this activity was severely attenuated in rabbits with lesions. These results support a general involvement of the cingulothalamic circuitry in instrumental approach and avoidance learning. The fact that learning consisted of response omission indicated that the cingulothalamic role is not limited to acquisition or production of active behavioral responses, such as locomotion. It is proposed that cingulothalamic neurons mediate associative attention, wherein enhanced neuronal responses to stimuli associated with reinforcement facilitate the selection and production of task-relevant responses.
Indexed as
Identifiers
12223575PMC6758115W2112681153What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.