ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2002
Metalloproteases and guidance of retinal axons in the developing visual system.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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Who cites it
30 citing papers in PubMed, 68 citations in OpenAlex.
- Elf3 deficiency during zebrafish development alters extracellular matrix organization and disrupts tissue morphogenesis.PloS one · 2022Article
- MMP2 Modulates Inflammatory Response during Axonal Regeneration in the Murine Visual System.Cells · 2021Article
- Matrix Metalloproteinases During Axonal Regeneration, a Multifactorial Role from Start to Finish.Molecular neurobiology · 2017Review
- Developmental expression of membrane type 4-matrix metalloproteinase (Mt4-mmp/Mmp17) in the mouse embryo.PloS one · 2017Article
- Cell adhesion and invasion mechanisms that guide developing axons.Current opinion in neurobiology · 2016Review
- Secreted frizzled related proteins modulate pathfinding and fasciculation of mouse retina ganglion cell axons by direct and indirect mechanisms.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- IgLON cell adhesion molecules are shed from the cell surface of cortical neurons to promote neuronal growth.The Journal of biological chemistry · 2015Article
- Regulation of ECM degradation and axon guidance by growth cone invadosomes.Development (Cambridge, England) · 2015Article
- Inhibition of MMP-2 but not MMP-9 influences inner ear spiral ganglion neurons in vitro.Cellular and molecular neurobiology · 2014Article
- Connecting the retina to the brain.ASN neuro · 2014Review
- Matrix metalloproteinase 14 in the zebrafish: an eye on retinal and retinotectal development.PloS one · 2013Article
- Lectican proteoglycans, their cleaving metalloproteinases, and plasticity in the central nervous system extracellular microenvironment.Neuroscience · 2012Review
- Matrix metalloproteinases in neuropathic pain and migraine: friends, enemies, and therapeutic targets.Pain research and treatment · 2012Article
- Regulation of axonal outgrowth and pathfinding by integrin-ECM interactions.Developmental neurobiology · 2011Review
- Deafferentation-induced redistribution of MMP-2, but not of MMP-9, depends on the emergence of GAP-43 positive axons in the adult rat cochlear nucleus.Neural plasticity · 2011Article
- Metzincin proteases and their inhibitors: foes or friends in nervous system physiology?The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Review
- Xenopus sonic hedgehog guides retinal axons along the optic tract.Developmental dynamics : an official publication of the American Association of Anatomists · 2010Article
- Long-term expression of tissue-inhibitor of matrix metalloproteinase-1 in the murine central nervous system does not alter the morphological and behavioral phenotype but alleviates the course of experimental allergic encephalomyelitis.The American journal of pathology · 2010Article
- Dynamic expression of axon guidance cues required for optic tract development is controlled by fibroblast growth factor signaling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Molecular/genetic manipulation of extrinsic axon guidance factors for CNS repair and regeneration.Experimental neurology · 2008Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Axonal growth cones read cues in their environment that guide them to their target. Metalloproteases have been implicated in vitro in modulating the interaction of these cues with receptors in the growth cone. To determine whether metalloprotease function is important in the guidance of vertebrate axons in vivo, we applied hydroxamate-based metalloprotease inhibitors to Xenopus retinal ganglion cell (RGC) axons as they extended through the optic tract. In the presence of two different inhibitors, 0.5-20 microm N-[(2R)-2(hydroxamideocarbonylmethyl)-4-methylpantanoyl]-l-tryptophan methylamide and batimastat, RGC axons made similar dose-dependent guidance errors. Most axons failed to make the expected caudal turn in the diencephalon and continued straight, growing aberrantly toward and across the dorsal midline. As a result, few RGC axons innervated their midbrain target, the optic tectum. Similarly, if the inhibitors were applied after the axons made the turn, many failed to grow into the optic tectum and instead turned to grow along its anterior border. Interestingly, in many instances pathfinding defects were observed in the absence of problems with axon extension, although outgrowth was impaired at the higher doses of the inhibitors. These data provide compelling in vivo evidence that metalloproteases are important for both axon guidance and extension in the developing visual system.
Indexed as
Identifiers
12223563PMC6758082W2167446612What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.