ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2002
Three functionally distinct adhesions in filopodia: shaft adhesions control lamellar extension.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 105 citations in OpenAlex.
- Long-range axon branching: contributions to brain network plasticity and repair.Nature reviews. Neuroscience · 2026Review
- Induction of filopodia formation by α-Actinin-2 via RelA with a feedforward activation loop promoting overt bone marrow metastasis of gastric cancer.Journal of translational medicine · 2023Article
- Activated I-BAR IRSp53 clustering controls the formation of VASP-actin-based membrane protrusions.Science advances · 2022Article
- Enhanced mechanosensing of cells in synthetic 3D matrix with controlled biophysical dynamics.Nature communications · 2021Article
- Active perception during angiogenesis: filopodia speed up Notch selection of tip cellsPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Article
- Cellular response of human apical papilla cells to calcium hydroxide and tricalcium silicate-based cements.BMC oral health · 2021Article
- Biomechanical Aspects of Actin Bundle Dynamics.Frontiers in cell and developmental biology · 2020Article
- Roles for Ena/VASP proteins in FMNL3-mediated filopodial assembly.Journal of cell science · 2018Article
- Myosin X is recruited to nascent focal adhesions at the leading edge and induces multi-cycle filopodial elongation.Scientific reports · 2017Article
- Asymmetric division coordinates collective cell migration in angiogenesis.Nature cell biology · 2016Article
- Actin filament-microtubule interactions in axon initiation and branching.Brain research bulletin · 2016Review
- PCP Signaling between Migrating Neurons and their Planar-Polarized Neuroepithelial Environment Controls Filopodial Dynamics and Directional Migration.PLoS genetics · 2016Article
- Cell Invasion Dynamics into a Three Dimensional Extracellular Matrix Fibre Network.PLoS computational biology · 2015Article
- Promoting filopodial elongation in neurons by membrane-bound magnetic nanoparticles.Nanomedicine : nanotechnology, biology, and medicine · 2015Article
- The effects of confinement on neuronal growth cone morphology and velocity.Biomaterials · 2014Article
- Regulation of intrinsic axon growth ability at retinal ganglion cell growth cones.Investigative ophthalmology & visual science · 2014Article
- Maturation of filopodia shaft adhesions is upregulated by local cycles of lamellipodia advancements and retractions.PloS one · 2014Article
- Macrophages lift off surface-bound bacteria using a filopodium-lamellipodium hook-and-shovel mechanism.Scientific reports · 2013Article
- Mitochondrial Dynamics in Retinal Ganglion Cell Axon Regeneration and Growth Cone Guidance.Journal of ocular biology · 2013Article
- Cell guidance on nanogratings: a computational model of the interplay between PC12 growth cones and nanostructures.PloS one · 2013Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
In this study, adhesions on individual filopodial shafts were shown to control veil (lamellar) advance and to be modulated by guidance cues. Adhesions were detected in individual filopodia of sensory growth cones using optical recordings, adhesion markers, and electron microscopy. Veils readily advanced along filopodia lacking shaft adhesions but rarely advanced along filopodia displaying shaft adhesions. Experiments altering adhesion showed that this relationship is not caused by veils removing adhesions as they advanced. Reducing adhesion with antibodies decreased the proportion of filopodia with shaft adhesions and coordinately increased veil advance. Moreover, the inhibitory relationship was maintained: veils still failed to advance on individual filopodia that retained shaft adhesions. These results support the idea that shaft adhesions inhibit veil advance. Of particular interest, guidance cues can act by altering shaft adhesions. When a cellular cue was contacted by a filopodial tip, veil extension and shaft adhesions altered in concert. Contact with a Schwann cell induced veil advance and inhibited shaft adhesions. In contrast, contact with a posterior sclerotome cell prohibited veil advance and promoted shaft adhesions. These results show that veil advance is controlled by shaft adhesions and that guidance signal cascades can alter veil advance by altering these adhesions. Shaft adhesions thus differ functionally from two other adhesions identified on individual filopodia. Tip adhesions suffice to signal. Basal adhesions do not influence veil advance but are critical to filopodial initiation and dynamics. Individual growth cone filopodia thus develop three functionally distinct adhesions that are vital for both motility and navigation.
Indexed as
Identifiers
12223561PMC6758076W2162768868What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.