ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2002
The AMPA receptor subunit GluR1 regulates dendritic architecture of motor neurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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Who cites it
36 citing papers in PubMed, 82 citations in OpenAlex.
- Exploring the microbiota-gut-brain axis: impact on brain structure and function.Frontiers in neuroanatomy · 2025Review
- The long noncoding RNA nHOTAIRM1 is necessary for differentiation and activity of iPSC-derived spinal motor neurons.Cell death & disease · 2023Article
- Extracellular molecular signals shaping dendrite architecture during brain development.Frontiers in cell and developmental biology · 2023Review
- Molecular Identification of Pro-Excitogenic Receptor and Channel Phenotypes of the Deafferented Lumbar Motoneurons in the Early Phase after SCT in Rats.International journal of molecular sciences · 2022Article
- Synaptic dysfunction in ALS and FTD: anatomical and molecular changes provide insights into mechanisms of disease.Frontiers in molecular neuroscience · 2022Review
- Reelin restricts dendritic growth of interneurons in the neocortex.Development (Cambridge, England) · 2021Article
- Article
- A Method to Investigate Astrocyte and Microglial Morphological Changes in the Aging Brain of the Rhesus Macaque.Methods in molecular biology (Clifton, N.J.) · 2019Article
- Cyclophilin D regulates neuronal activity-induced filopodiagenesis by fine-tuning dendritic mitochondrial calcium dynamics.Journal of neurochemistry · 2018Article
- SPARC and GluA1-Containing AMPA Receptors Promote Neuronal Health Following CNS Injury.Frontiers in cellular neuroscience · 2018Article
- Glycinergic Neurotransmission: A Potent Regulator of Embryonic Motor Neuron Dendritic Morphology and Synaptic Plasticity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Emerging Roles of Filopodia and Dendritic Spines in Motoneuron Plasticity during Development and Disease.Neural plasticity · 2016Review
- Structure-function analysis of SAP97, a modular scaffolding protein that drives dendrite growth.Molecular and cellular neurosciences · 2015Article
- GluA1 promotes the activity-dependent development of motor circuitry in the developing segmental spinal cord.Annals of the New York Academy of Sciences · 2013Review
- The molecular basis of experience-dependent motor system development.Advances in experimental medicine and biology · 2013Article
- Homeostatic regulation of dendritic dynamics in a motor map in vivo.Nature communications · 2013Article
- Electrical activity as a developmental regulator in the formation of spinal cord circuits.Current opinion in neurobiology · 2012Review
- Calcium/calmodulin-dependent protein kinase IV mediates distinct features of basal and activity-dependent dendrite complexity.Neuroscience · 2011Article
- Distinct AMPA-type glutamatergic synapses in developing rat CA1 hippocampus.Journal of neurophysiology · 2010Article
- A role for RhoB in synaptic plasticity and the regulation of neuronal morphology.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
Abstract
The morphology of the mature motor neuron dendritic arbor is determined by activity-dependent processes occurring during a critical period in early postnatal life. The abundance of the AMPA receptor subunit GluR1 in motor neurons is very high during this period and subsequently falls to a negligible level. To test the role of GluR1 in dendrite morphogenesis, we reintroduced GluR1 into rat motor neurons at the end of the critical period and quantitatively studied the effects on dendrite architecture. Two versions of GluR1 were studied that differed by the amino acid in the "Q/R" editing site. The amino acid occupying this site determines single-channel conductance, ionic permeability, and other essential electrophysiologic properties of the resulting receptor channels. We found large-scale remodeling of dendritic architectures in a manner depending on the amino acid occupying the Q/R editing site. Alterations in the distribution of dendritic arbor were not prevented by blocking NMDA receptors. These observations suggest that the expression of GluR1 in motor neurons modulates a component of the molecular substrate of activity-dependent dendrite morphogenesis. The control of these events relies on subunit-specific properties of AMPA receptors.
Indexed as
Identifiers
12223558PMC6758079W1566958459What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.