Evidence map›Paper›PMID 12223547›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2002

A novel signaling pathway of nitric oxide on transcriptional regulation of mouse kappa opioid receptor gene.

Sung Wook Park, Jinhua Li, Horace H Loh, Li-Na Wei

Open access · bronzeAbstract read
PubMed Full text at PMC
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
  2. Epigenetic Modulation of Opioid Receptors by Drugs of Abuse.International journal of molecular sciences · 2022
    Review
  3. Opioids Resistance in Chronic Pain Management.Current neuropharmacology · 2017
    Review
  4. Stress-induced epigenetic regulation of κ-opioid receptor gene involves transcription factor c-Myc.Proceedings of the National Academy of Sciences of the United States of America · 2012
    Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Axonal mRNA transport and localized translational regulation of kappa-opioid receptor in primary neurons of dorsal root ganglia.Proceedings of the National Academy of Sciences of the United States of America · 2006
    Article
  10. Netrin-1 signaling regulates de novo protein synthesis of kappa opioid receptor by facilitating polysomal partition of its mRNA.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006
    Article
  11. Nuclear factor kappaB signaling in opioid functions and receptor gene expression.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2006
    Review
  12. Retinoic acid-induced chromatin remodeling of mouse kappa opioid receptor gene.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005
    Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Sung Wook ParkDepartment of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA.
Jinhua Li
Horace H Loh
Li-Na Wei
University of Minnesota Medical Center · US

Funding

Subcellular Targeting/Packaging of Opioids/ReceptorsP50DA011806 · NIDA · UNIVERSITY OF MINNESOTA TWIN CITIES · PI LOH, HORACE · 1998 to 2012
$14.0M
Studies of nuclear receptor corepressor, NRIP1, in vitamin A signaling pathwaysR01DK060521 · NIDDK · UNIVERSITY OF MINNESOTA TWIN CITIES · PI WEI, LI-NA · 2002 to 2022
$6.9M
TR2 NUCLEAR RECEPTOR IN VITAMIN A SIGNALING PATHWAYSR01DK054733 · NIDDK · UNIVERSITY OF MINNESOTA TWIN CITIES · PI WEI, LI-NA · 1999 to 2021
$5.7M
NEUROCHEMICAL BASIS ON NARCOTIC ADDICTIONR01DA000564 · NIDA · UNIVERSITY OF MINNESOTA TWIN CITIES · PI LOH, HORACE · 1985 to 2010
$5.1M
Studies of Mouse Kappa Opioid Receptor Gene RegulationR01DA011190 · NIDA · UNIVERSITY OF MINNESOTA TWIN CITIES · PI WEI, LI-NA · 1997 to 2011
$3.3M
Neurochemical Basis of Opiate AddictionR56DA000564 · NIDA · UNIVERSITY OF MINNESOTA · PI LAW, PING-YEE, LOH, HORACE · 2012 to 2013
$329k
NIDA NIH HHS DA00564NIDA NIH HHS DA11190NIDA NIH HHS DA11806NIDA NIH HHS P50 DA011806NIDA NIH HHS R01 DA000564NIDA NIH HHS R01 DA011190NIDA NIH HHS R56 DA000564NIDDK NIH HHS DK54733NIDDK NIH HHS DK60521NIDDK NIH HHS R01 DK054733NIDDK NIH HHS R01 DK060521
6 · The paper itself

Abstract

Nitric oxide (NO) suppressed the transcription of the mouse kappa opioid receptor (KOR) gene, mediated by a rapid downregulation of c-myc gene expression. KOR was constitutively expressed in postnatal day 19 (P19) embryonal carcinoma stem cells and is suppressed by NO donors [sodium nitroprusside (SNP), 3-morpholinosydnonimine-1, and S-nitrosoglutathione] in P19 stem cells within 4 hr. The suppression was reversed by 2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide, an NO scavenger, but could not be blocked by dithiothreitol, ruling out S-nitrosylation as the underlying mechanism. The suppressive effect of NO on KOR occurred at the level of gene transcription, mediated by E boxes located in promoters I and II of this gene. Protein-DNA complexes that formed on these E boxes contained c-myc; c-myc expression was suppressed by NO in P19 stem cells within 2 hr of treatment. Furthermore, chromatin immunoprecipitation demonstrated reduced c-myc binding to the E boxes and hypoacetylation of histone H3 on the chromatin of endogenous KOR promoters in P19 stem cells treated with SNP. It is proposed that NO regulates KOR at the level of gene transcription, mediated by a rapid suppression of c-myc gene expression and its binding to KOR promoters, and followed by chromatin hypoacetylation of and reduced transcription from KOR promoters in P19 stem cells. A novel pathway mediating the potential interplay between NO and opioid systems is discussed.

Indexed as

AcetylationAnimalsCarcinoma, EmbryonalChromatinDNAFree Radical ScavengersGene Expression RegulationHistonesMacromolecular SubstancesMiceNitric OxideNitric Oxide DonorsPromoter Regions, GeneticProto-Oncogene Proteins c-mycReceptors, Opioid, kappaReducing AgentsChromatinDNAFree Radical ScavengersHistonesMacromolecular SubstancesNitric OxideNitric Oxide DonorsProto-Oncogene Proteins c-mycReceptors, Opioid, kappaReducing AgentsRNA, Messenger

Identifiers

PMID12223547
PMCPMC6758116
OpenAlexW2102459919

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.