ReviewBreast cancer research : BCR2002
Progesterone's role in mammary gland development and tumorigenesis as disclosed by experimental mouse genetics.
Review in Breast cancer research : BCR, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 45 citations in OpenAlex.
- Article
- Role of pregnancy hormones and hormonal interaction on the maternal cardiovascular system: a literature review.Clinical research in cardiology : official journal of the German Cardiac Society · 2019Review
- Progesterone impairs Herceptin effect on breast cancer cells.Oncology letters · 2018Article
- Steroid hormone receptors as prognostic markers in breast cancer.American journal of cancer research · 2017Review
- Establishing estrogen-responsive mouse mammary organoids from single Lgr5Cellular signalling · 2017Article
- Molecular Signaling of Progesterone, Growth Hormone, Wnt, and HER in Mammary Glands of Dogs, Rodents, and Humans: New Treatment Target Identification.Frontiers in veterinary science · 2017Review
- Fibroblast growth factor signalling induces loss of progesterone receptor in breast cancer cells.Oncotarget · 2016Article
- Pttg1/securin is required for the branching morphogenesis of the mammary gland and suppresses mammary tumorigenesis.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- The biology of progesterone receptor in the normal mammary gland and in breast cancer.Molecular and cellular endocrinology · 2012Review
- MiR-126-3p regulates progesterone receptors and involves development and lactation of mouse mammary gland.Molecular and cellular biochemistry · 2011Article
- The antiproliferative effects of progestins in T47D breast cancer cells are tempered by progestin induction of the ETS transcription factor Elf5.Molecular endocrinology (Baltimore, Md.) · 2010Article
- Hormonal and local control of mammary branching morphogenesis.Differentiation; research in biological diversity · 2006Review
- Key stages in mammary gland development: the cues that regulate ductal branching morphogenesis.Breast cancer research : BCR · 2006Review
- Steroid receptor RNA activator stimulates proliferation as well as apoptosis in vivo.Molecular and cellular biology · 2003Article
- Isolation and characterization of functional mammary gland stem cells.Cell proliferation · 2003Review
- Progesterone receptors in mammary gland development and tumorigenesis.Journal of mammary gland biology and neoplasia · 2003Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The progesterone receptor knockout mouse demonstrated progesterone's importance to parity-induced mammary tertiary branching and lobuloalveologenesis. Because early parity provides significant protection against breast cancer whereas prolonged exposure to premenopausal ovarian progesterone (or to postmenopausal supplementations thereof) has been linked to breast cancer risk, this steroid can be considered to exhibit contrasting roles in breast cancer etiology. This review describes the important mouse models that have contributed to our understanding of progesterone's role in mammary gland development and neoplasia. We conclude by emphasising the urgent need to identify the molecular targets of the progesterone receptor, and to determine whether these targets are modulated differently by the progesterone receptor isoforms (A and B) during mammary morphogenesis and tumorigenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.