ArticleJournal of neuro-oncology2002
Good clinical course in infants with desmoplastic cerebral neuroepithelial tumor treated by surgery alone.
Article in Journal of neuro-oncology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- Predictors of mortality and tumor recurrence in desmoplastic infantile ganglioglioma and astrocytoma-and individual participant data meta-analysis (IPDMA).Journal of neuro-oncology · 2021Pooled it
- Chromosomal instability: a key driver in glioma pathogenesis and progression.European journal of medical research · 2024Review
- Desmoplastic infantile astrocytoma with atypical phenotype, PTEN homozygous deletion and BRAF V600E mutation.Acta neuropathologica communications · 2022Article
- The molecular characteristics of low-grade and high-grade areas in desmoplastic infantile astrocytoma/ganglioglioma.Neuropathology and applied neurobiology · 2022Article
- Desmoplastic infantile astrocytoma and ganglioglioma: a series of 12 patients treated at a single institution.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2021Article
- Pediatric Low-Grade Gliomas.Cancers · 2020Review
- Desmoplastic infantile ganglioglioma.The Pan African medical journal · 2019Article
- Desmoplastic Infantile Ganglioglioma/Astrocytoma (DIG/DIA) Are Distinct Entities with Frequent BRAFV600 Mutations.Molecular cancer research : MCR · 2018Article
- Novel suprasellar location of desmoplastic infantile astrocytoma and ganglioglioma: a single institution's experience.Journal of neurosurgery. Pediatrics · 2018Article
- Perinatal (fetal and neonatal) astrocytoma: a review.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2016Review
- Desmoplastic astrocytoma: new insights into its clinical profile, diagnosis, and treatment.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2016Review
- Diffusion, Perfusion, and Histopathologic Characteristics of Desmoplastic Infantile Ganglioglioma.Journal of radiology case reports · 2016Review
- Desmoplastic infantile and non-infantile ganglioglioma. Review of the literature.Neurosurgical review · 2010Review
- A report of a desmoplastic non-infantile ganglioglioma in a 6-year-old boy with review of the literature.Neurosurgical review · 2009Article
- A report of a desmoplastic ganglioglioma in a 12-year-old girl with review of the literature.Journal of neuro-oncology · 2006Article
- A non-infantile case of desmoplastic infantile astrocytoma.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2004Article
- Desmoplastic infantile ganglioglioma/astrocytoma: Expanding the molecular and morphological spectrum with a novel BRAF fusion.Neuro-oncology advancesArticle
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We investigated why surgery alone provides for a benign clinical course in patients with desmoplastic infantile ganglioglioma and astrocytoma (DIG/A). The clinical course of 4, less than six-month-old girls, surgically treated at our institutions, was evaluated retrospectively. All presented with the clinical symptom of increasing head circumference. CT and MRI scans revealed a solid tumor attached to the dura that was surrounded by large, multiple cysts, in fronto-temporo-parietal lobe. Gross total removal succeeded in all 4 cases because the solid components of the tumor were very firm in contrast to the soft adjacent brain tissue. Microscopically, the surgical specimens consisted almost entirely of dense fibrous connective tissue containing generally elongate cells with inconspicuous cytoplasm. Most of these cells were immunopositive for GFAP. There was no evidence of tumor cells in the cyst wall. In 3 cases, some small neurons were positive for neurofilament immunostain. A high proportion of undifferentiated small cells in a less demoplastic area far from the dura were immunopositive for MIB-1. All of the 4 patients have been free of recurrence for more than five years. In patients with DIG/A, there are 5 reasons for a good clinical course. [1] At surgery, the tumor margin is clearly discernible because of the difference between the solid tumor and the soft adjacent brain tissue. [2] The tumor is located in the superficial cerebral hemisphere. [3] Large, multiple cysts surround the tumor. [4] The growth point appears to be adjacent to the cysts. [5] The cyst walls are free of invading tumor cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.