ArticleJournal of neuro-oncology2002
Are childhood and adult medulloblastomas different? A comparative study of clinicopathological features, proliferation index and apoptotic index.
Article in Journal of neuro-oncology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 88 citations in OpenAlex.
- Radiological progression of medulloblastoma from non-existence to symptomatic mass in 42 days: Case report, kinetic analysis, and literature review.Brain & spine · 2025Article
- Peritoneal metastasis of a cerebellar medulloblastoma through a ventriculoperitoneal shunt: A case report.Radiology case reports · 2024Article
- Regulation of Chemosensitivity in Human Medulloblastoma Cells by p53 and the PI3 Kinase Signaling Pathway.Molecular cancer research : MCR · 2022Article
- Preoperative Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio are Associated with the Prognosis of Group 3 and Group 4 Medulloblastoma.Scientific reports · 2019Article
- Prognostic value of Ki-67 index in adult medulloblastoma after accounting for molecular subgroup: a retrospective clinical and molecular analysis.Journal of neuro-oncology · 2018Article
- Article
- Human corticotrophin releasing factor inhibits cell proliferation and promotes apoptosis through upregulation of tumor protein p53 in human glioma.Oncology letters · 2018Article
- [Value of diffusion-weighted imaging,Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2017Article
- Clinicopathological characteristics, molecular subgrouping, and expression of miR-379/miR-656 cluster (C14MC) in adult medulloblastomas.Journal of neuro-oncology · 2016Article
- Isolated Supratentorial Intraventricular Recurrence of Medulloblastoma.Journal of Korean Neurosurgical Society · 2015Article
- [Medulloblastoma in adults: report of 13 cases and literature review].The Pan African medical journal · 2015Review
- Incidence and relative survival of anaplastic astrocytomas.Neuro-oncology · 2014Article
- Long-term outcomes and role of chemotherapy in adults with newly diagnosed medulloblastoma.American journal of clinical oncology · 2014Article
- Article
- The adolescent and young adult with cancer: state of the art--brain tumor.Current oncology reports · 2013Review
- Multifocal presentation of medulloblastoma in adulthood.Journal of neuro-oncology · 2012Review
- A study of histopathological spectrum and expression of Ki-67, TP53 in primary brain tumors of pediatric age group.Indian journal of medical and paediatric oncology : official journal of Indian Society of Medical & Paediatric Oncology · 2012Article
- Lack of prognostic significance of survivin in pediatric medulloblastoma.Pathology oncology research : POR · 2011Article
- Outcome and prognostic factors of desmoplastic medulloblastoma treated within a multidisciplinary treatment concept.BMC cancer · 2010Article
- Medulloblastomas: a correlative study of MIB-1 proliferation index along with expression of c-Myc, ERBB2, and anti-apoptotic proteins along with histological typing and clinical outcome.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2009Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Childhood medulloblastomas have been suspected to be biologically different from adult tumors, though comparative studies are sparse in the literature. The present study aims to establish any differences or nexus in the biological characteristics between childhood and adult medulloblastomas. A total of 181 medulloblastomas were studied with respect to clinical and histological characteristics, MIB-1 labeling index (MIB-1 LI), apoptotic index (AI), ratio of apoptotic to LI, p53 and Bcl-2 protein expressions. Two-thirds (112) of the 181 medulloblastomas occurred in children (< or = 15 years) and 69 in adults (> 15 years). Childhood tumors were more commonly of classical histology and midline location while the desmoplastic variant and lateral location occurred more frequently in adults. Adult medulloblastomas were biologically less aggressive, having lower growth rate parameters (mean MIB-1 LI 19.1 +/- 15.7; AI 3.73 +/- 2.71 and AI:LI 0.207 +/- 0.162) as compared to childhood tumors (mean MIB-1 LI 28.3 +/- 20.4; AI 2.86 +/- 2.14 and AI:LI 0.108 +/- 0.111). p53 and Bcl-2 protein expressions were infrequent in all groups of tumors. No difference was noted in any of the parameters when classical and desmoplastic medulloblastomas were compared as a whole. But when compared between the age groups, an interesting observation (hitherto unreported in English literature) was that both classical and desmoplastic variants of childhood medulloblastomas had higher LI, lower AI and lower AI:LI ratio than their counterparts in adults, indicating that differences in growth rates cannot be attributed to differences in the frequency of occurrence of the histological variants in the two age groups. Thus, this study conclusively shows that there is a biological difference between childhood and adult medulloblastomas which is independent of standard histology and appeared to be associated more with age-related factors. This also warrants less-aggressive therapy for adult medulloblastoma.
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