ArticleJournal of muscle research and cell motility2001
Content and localization of myostatin in mouse skeletal muscles during aging, mechanical unloading and reloading.
Article in Journal of muscle research and cell motility, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 72 citations in OpenAlex.
- Effect of Mechanical Loading of Senescent Myoblasts on Their Myogenic Lineage Progression and Survival.Cells · 2022Article
- Changes Induced by Aging and Long-Term Exercise and/or DHA Supplementation in Muscle of Obese Female Mice.Nutrients · 2022Article
- Skeletal Muscle Recovery from Disuse Atrophy: Protein Turnover Signaling and Strategies for Accelerating Muscle Regrowth.International journal of molecular sciences · 2020Review
- Changes in Lean Mass and Serum Myostatin with Habitual Protein Intake and High-Velocity Resistance Training.The journal of nutrition, health & aging · 2017Article
- Myostatin and the skeletal muscle atrophy and hypertrophy signaling pathways.Cellular and molecular life sciences : CMLS · 2014Review
- L-leucine, beta-hydroxy-beta-methylbutyric acid (HMB) and creatine monohydrate prevent myostatin-induced Akirin-1/Mighty mRNA down-regulation and myotube atrophy.Journal of the International Society of Sports Nutrition · 2014Article
- Association of the K153R polymorphism in the myostatin gene and extreme longevity.Age (Dordrecht, Netherlands) · 2013Article
- Murine models of atrophy, cachexia, and sarcopenia in skeletal muscle.Biochimica et biophysica acta · 2013Review
- Myostatin suppression of Akirin1 mediates glucocorticoid-induced satellite cell dysfunction.PloS one · 2013Article
- The effect of physiological stimuli on sarcopenia; impact of Notch and Wnt signaling on impaired aged skeletal muscle repair.International journal of biological sciences · 2012Review
- Effect of aging on cellular mechanotransduction.Ageing research reviews · 2011Review
- Blocking the myostatin signal with a dominant negative receptor improves the success of human myoblast transplantation in dystrophic mice.Molecular therapy : the journal of the American Society of Gene Therapy · 2011Article
- A modified enrichment protocol for adult caprine skeletal muscle stem cell.Cytotechnology · 2010Article
- Skeletal muscle wasting in cachexia and sarcopenia: molecular pathophysiology and impact of exercise training.Journal of cachexia, sarcopenia and muscle · 2010Article
- Sarcopenia: etiology, clinical consequences, intervention, and assessment.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2010Review
- Myostatin and follistatin polymorphisms interact with muscle phenotypes and ethnicity.Medicine and science in sports and exercise · 2009Article
- Myostatin in the pathophysiology of skeletal muscle.Current genomics · 2007Article
- Effects of resistance training on older adults.Sports medicine (Auckland, N.Z.) · 2004Review
- Global analysis of gene expression patterns during disuse atrophy in rat skeletal muscle.The Journal of physiology · 2003Article
- Time- and exercise-dependent gene regulation in human skeletal muscle.Genome biology · 2003Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Changes in myostatin content and localization in mouse skeletal muscles were investigated during aging, hindlimb suspension (HS) and reloading after HS. During aging, the content of myostatin among solubilized proteins in gastrocnemius and plantaris muscles (Gast/Plant) was initially low and increased until their wet weight/body weight ratio reached a peak. It remained unchanged with further aging, although gradual atrophy of the muscles was seen to occur. Also, the myostatin content did not change significantly during HS (up to 14 days) in both Gast/Plant and soleus muscles, though the muscles showed morphological signs of atrophy. However, reloading for 2 days after a 14-day HS caused significant decreases in the myostatin content in both of these muscles. Immunohistochemical observations showed the sarcoplasmic existence of myostatin, the amount of which appeared to decrease after reloading. The results suggest that myostatin plays a part in the processes of muscular growth and loading-induced hypertrophy, but is not involved in either aging-related or unloading-induced muscular atrophy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.